The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy

Samuel A. Shelburne, Jorge Darcourt, A. Clinton White, Stephen B. Greenberg, Richard J. Hamill, Robert L. Atmar, Fehmida Visnegarwala

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.

Original languageEnglish (US)
Pages (from-to)1049-1052
Number of pages4
JournalClinical Infectious Diseases
Volume40
Issue number7
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

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Immune Reconstitution Inflammatory Syndrome
Cryptococcus neoformans
Highly Active Antiretroviral Therapy
Acquired Immunodeficiency Syndrome
HIV
Cerebrospinal Fluid Pressure
Leukocyte Count
Meningitis
Glucose

ASJC Scopus subject areas

  • Immunology

Cite this

The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy. / Shelburne, Samuel A.; Darcourt, Jorge; White, A. Clinton; Greenberg, Stephen B.; Hamill, Richard J.; Atmar, Robert L.; Visnegarwala, Fehmida.

In: Clinical Infectious Diseases, Vol. 40, No. 7, 01.04.2005, p. 1049-1052.

Research output: Contribution to journalArticle

Shelburne, Samuel A. ; Darcourt, Jorge ; White, A. Clinton ; Greenberg, Stephen B. ; Hamill, Richard J. ; Atmar, Robert L. ; Visnegarwala, Fehmida. / The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy. In: Clinical Infectious Diseases. 2005 ; Vol. 40, No. 7. pp. 1049-1052.
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