The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy

Samuel A. Shelburne, Jorge Darcourt, A. Clinton White, Stephen B. Greenberg, Richard J. Hamill, Robert L. Atmar, Fehmida Visnegarwala

Research output: Contribution to journalArticle

250 Scopus citations


This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.

Original languageEnglish (US)
Pages (from-to)1049-1052
Number of pages4
JournalClinical Infectious Diseases
Issue number7
StatePublished - Apr 1 2005


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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