The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy

Samuel A. Shelburne; Jorge Darcourt; A. Clinton White; Stephen B. Greenberg; Richard J. Hamill; Robert L. Atmar; Fehmida Visnegarwala

doi:10.1086/428618

The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy

Samuel A. Shelburne
, Jorge Darcourt
, A. Clinton White
, Stephen B. Greenberg
, Richard J. Hamill
, Robert L. Atmar
, Fehmida Visnegarwala

Research output: Contribution to journal › Article › peer-review

295 Scopus citations

Abstract

This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.

Original language	English (US)
Pages (from-to)	1049-1052
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	40
Issue number	7
DOIs	https://doi.org/10.1086/428618
State	Published - Apr 1 2005
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/428618

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title = "The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy",

abstract = "This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30\% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.",

author = "Shelburne, \{Samuel A.\} and Jorge Darcourt and White, \{A. Clinton\} and Greenberg, \{Stephen B.\} and Hamill, \{Richard J.\} and Atmar, \{Robert L.\} and Fehmida Visnegarwala",

note = "Funding Information: We thank Dr. Thomas Giordano and Dr. Robert Lasky for assistance with statistical analysis. Financial support. Bristol-Myers Squibb (HIV fellowship grant to S.A.S.) and the National Institute of Allergy and Infectious Diseases (fellowship grant T32-AI055413 to S.A.S.). Potential conflicts of interest. All authors: no conflicts.",

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AU - Greenberg, Stephen B.

AU - Hamill, Richard J.

AU - Atmar, Robert L.

AU - Visnegarwala, Fehmida

N1 - Funding Information: We thank Dr. Thomas Giordano and Dr. Robert Lasky for assistance with statistical analysis. Financial support. Bristol-Myers Squibb (HIV fellowship grant to S.A.S.) and the National Institute of Allergy and Infectious Diseases (fellowship grant T32-AI055413 to S.A.S.). Potential conflicts of interest. All authors: no conflicts.

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N2 - This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.

AB - This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). Patients with C. neoformans-related IRIS had higher cerebrospinal fluid opening pressures, glucose levels, and white blood cell counts, compared with patients with typical HIV-associated C. neoformans meningitis.

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The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy

Abstract

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