The role of innate immunity in conditioning mosquito susceptibility to West Nile virus

Abhishek N. Prasad; Doug E. Brackney; Gregory D. Ebel

doi:10.3390/v5123142

The role of innate immunity in conditioning mosquito susceptibility to West Nile virus

Abhishek N. Prasad, Doug E. Brackney, Gregory D. Ebel

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.

Original language	English (US)
Pages (from-to)	3142-3170
Number of pages	29
Journal	Viruses
Volume	5
Issue number	12
DOIs	https://doi.org/10.3390/v5123142
State	Published - Dec 13 2013
Externally published	Yes

Keywords

Apoptosis
Arbovirus
Autophagy
Imd
Innate immunity
Jak/STAT
Mosquito
RNAi
Toll
West Nile virus

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v5123142

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abstract = "Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.",

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AU - Brackney, Doug E.

AU - Ebel, Gregory D.

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AB - Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.

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KW - Autophagy

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KW - Mosquito

KW - RNAi

KW - Toll

KW - West Nile virus

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The role of innate immunity in conditioning mosquito susceptibility to West Nile virus

Abstract

Keywords

ASJC Scopus subject areas

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