The role of innate immunity in conditioning mosquito susceptibility to West Nile virus

Abhishek Prasad, Doug E. Brackney, Gregory D. Ebel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.

Original languageEnglish (US)
Pages (from-to)3142-3170
Number of pages29
JournalViruses
Volume5
Issue number12
DOIs
StatePublished - Dec 13 2013
Externally publishedYes

Fingerprint

Arboviruses
West Nile virus
Culicidae
Innate Immunity
Viruses
Livestock
Virus Diseases
Ecology
Mental Competency
Health
Conditioning (Psychology)

Keywords

  • Apoptosis
  • Arbovirus
  • Autophagy
  • Imd
  • Innate immunity
  • Jak/STAT
  • Mosquito
  • RNAi
  • Toll
  • West Nile virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

The role of innate immunity in conditioning mosquito susceptibility to West Nile virus. / Prasad, Abhishek; Brackney, Doug E.; Ebel, Gregory D.

In: Viruses, Vol. 5, No. 12, 13.12.2013, p. 3142-3170.

Research output: Contribution to journalArticle

Prasad, Abhishek ; Brackney, Doug E. ; Ebel, Gregory D. / The role of innate immunity in conditioning mosquito susceptibility to West Nile virus. In: Viruses. 2013 ; Vol. 5, No. 12. pp. 3142-3170.
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