Abstract
Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3142-3170 |
| Number of pages | 29 |
| Journal | Viruses |
| Volume | 5 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 13 2013 |
| Externally published | Yes |
Fingerprint
Keywords
- Apoptosis
- Arbovirus
- Autophagy
- Imd
- Innate immunity
- Jak/STAT
- Mosquito
- RNAi
- Toll
- West Nile virus
ASJC Scopus subject areas
- Infectious Diseases
- Virology
Cite this
The role of innate immunity in conditioning mosquito susceptibility to West Nile virus. / Prasad, Abhishek; Brackney, Doug E.; Ebel, Gregory D.
In: Viruses, Vol. 5, No. 12, 13.12.2013, p. 3142-3170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of innate immunity in conditioning mosquito susceptibility to West Nile virus
AU - Prasad, Abhishek
AU - Brackney, Doug E.
AU - Ebel, Gregory D.
PY - 2013/12/13
Y1 - 2013/12/13
N2 - Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.
AB - Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.
KW - Apoptosis
KW - Arbovirus
KW - Autophagy
KW - Imd
KW - Innate immunity
KW - Jak/STAT
KW - Mosquito
KW - RNAi
KW - Toll
KW - West Nile virus
UR - http://www.scopus.com/inward/record.url?scp=84890419190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890419190&partnerID=8YFLogxK
U2 - 10.3390/v5123142
DO - 10.3390/v5123142
M3 - Article
C2 - 24351797
AN - SCOPUS:84890419190
VL - 5
SP - 3142
EP - 3170
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 12
ER -