The role of innate immunity in conditioning mosquito susceptibility to West Nile virus

Abhishek N. Prasad, Doug E. Brackney, Gregory D. Ebel

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Arthropod-borne viruses (arboviruses) represent an emerging threat to human and livestock health globally. In particular, those transmitted by mosquitoes present the greatest challenges to disease control efforts. An understanding of the molecular basis for mosquito innate immunity to arbovirus infection is therefore critical to investigations regarding arbovirus evolution, virus-vector ecology, and mosquito vector competence. In this review, we discuss the current state of understanding regarding mosquito innate immunity to West Nile virus. We draw from the literature with respect to other virus-vector pairings to attempt to draw inferences to gaps in our knowledge about West Nile virus and relevant vectors.

Original languageEnglish (US)
Pages (from-to)3142-3170
Number of pages29
JournalViruses
Volume5
Issue number12
DOIs
StatePublished - Dec 13 2013

Keywords

  • Apoptosis
  • Arbovirus
  • Autophagy
  • Imd
  • Innate immunity
  • Jak/STAT
  • Mosquito
  • RNAi
  • Toll
  • West Nile virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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