The role of Mrgprs in pain

Dustin P. Green

doi:10.1016/j.neulet.2020.135544

The role of Mrgprs in pain

Dustin P. Green

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.

Original language	English (US)
Article number	135544
Journal	Neuroscience Letters
Volume	744
DOIs	https://doi.org/10.1016/j.neulet.2020.135544
State	Published - Jan 23 2021

Keywords

Mrgpr
Neuroimmune
Pain

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2020.135544

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title = "The role of Mrgprs in pain",

abstract = "Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.",

keywords = "Mrgpr, Neuroimmune, Pain",

author = "Green, {Dustin P.}",

note = "Funding Information: This work was supported by Neurosurgery Pain Research Institute Fellowship at Johns Hopkins University, School of Medicine and startup funding from Department of Neuroscience, Cell Biology and Anatomy at UTMB. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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AU - Green, Dustin P.

N1 - Funding Information: This work was supported by Neurosurgery Pain Research Institute Fellowship at Johns Hopkins University, School of Medicine and startup funding from Department of Neuroscience, Cell Biology and Anatomy at UTMB. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/1/23

Y1 - 2021/1/23

N2 - Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.

AB - Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.

KW - Mrgpr

KW - Neuroimmune

KW - Pain

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VL - 744

JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

The role of Mrgprs in pain

Abstract

Keywords

ASJC Scopus subject areas

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