The role of Mrgprs in pain

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8 Scopus citations


Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.

Original languageEnglish (US)
Article number135544
JournalNeuroscience Letters
StatePublished - Jan 23 2021


  • Mrgpr
  • Neuroimmune
  • Pain

ASJC Scopus subject areas

  • General Neuroscience


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