The role of neuropeptide processing enzymes in endocrine (Prostate) cancer: EC3.4.24.15 (EP24.15)

Todd Swanson, Sandra I. Kim, Michael Myers, Amanda Pabon, Keith D. Philibert, Mina Wang, Marc J. Glucksman

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The "neural" prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalProtein and Peptide Letters
Volume11
Issue number5
DOIs
StatePublished - Oct 2004
Externally publishedYes

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Keywords

  • Cancer
  • Endocrine
  • Metalloenzyme
  • Metallopeptidase
  • Neuropeptide
  • Prostate
  • Proteome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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