The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals

Mehdi Rasouli, Roya Fattahi, Ghader Nuoroozi, Zeinab Zarei-Behjani, Maliheh Yaghoobi, Zeinab Hajmohammadi, Simzar Hosseinzadeh

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Oxygen pressure plays an integral role in regulating various aspects of cellular biology. Cell metabolism, proliferation, morphology, senescence, metastasis, and angiogenesis are some instances that are affected by different tensions of oxygen. Hyperoxia or high oxygen concentration, enforces the production of reactive oxygen species (ROS) that disturbs physiological homeostasis, and consequently, in the absence of antioxidants, cells and tissues are directed to an undesired fate. On the other side, hypoxia or low oxygen concentration, impacts cell metabolism and fate strongly through inducing changes in the expression level of specific genes. Thus, understanding the precise mechanism and the extent of the implication of oxygen tension and ROS in biological events is crucial to maintaining the desired cell and tissue function for application in regenerative medicine strategies. Herein, a comprehensive literature review has been performed to find out the impacts of oxygen tensions on the various behaviors of cells or tissues.

Original languageEnglish (US)
Pages (from-to)195-215
Number of pages21
JournalCell and Tissue Banking
Volume25
Issue number1
DOIs
StatePublished - Mar 2024
Externally publishedYes

Keywords

  • Angiogenesis
  • Cancer
  • Cell morphology
  • Cell proliferation
  • Oxygen
  • ROS
  • Senescence

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Fingerprint

Dive into the research topics of 'The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals'. Together they form a unique fingerprint.

Cite this