TY - JOUR
T1 - The role of oxygen tension in cell fate and regenerative medicine
T2 - implications of hypoxia/hyperoxia and free radicals
AU - Rasouli, Mehdi
AU - Fattahi, Roya
AU - Nuoroozi, Ghader
AU - Zarei-Behjani, Zeinab
AU - Yaghoobi, Maliheh
AU - Hajmohammadi, Zeinab
AU - Hosseinzadeh, Simzar
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature B.V. 2023.
PY - 2024/3
Y1 - 2024/3
N2 - Oxygen pressure plays an integral role in regulating various aspects of cellular biology. Cell metabolism, proliferation, morphology, senescence, metastasis, and angiogenesis are some instances that are affected by different tensions of oxygen. Hyperoxia or high oxygen concentration, enforces the production of reactive oxygen species (ROS) that disturbs physiological homeostasis, and consequently, in the absence of antioxidants, cells and tissues are directed to an undesired fate. On the other side, hypoxia or low oxygen concentration, impacts cell metabolism and fate strongly through inducing changes in the expression level of specific genes. Thus, understanding the precise mechanism and the extent of the implication of oxygen tension and ROS in biological events is crucial to maintaining the desired cell and tissue function for application in regenerative medicine strategies. Herein, a comprehensive literature review has been performed to find out the impacts of oxygen tensions on the various behaviors of cells or tissues.
AB - Oxygen pressure plays an integral role in regulating various aspects of cellular biology. Cell metabolism, proliferation, morphology, senescence, metastasis, and angiogenesis are some instances that are affected by different tensions of oxygen. Hyperoxia or high oxygen concentration, enforces the production of reactive oxygen species (ROS) that disturbs physiological homeostasis, and consequently, in the absence of antioxidants, cells and tissues are directed to an undesired fate. On the other side, hypoxia or low oxygen concentration, impacts cell metabolism and fate strongly through inducing changes in the expression level of specific genes. Thus, understanding the precise mechanism and the extent of the implication of oxygen tension and ROS in biological events is crucial to maintaining the desired cell and tissue function for application in regenerative medicine strategies. Herein, a comprehensive literature review has been performed to find out the impacts of oxygen tensions on the various behaviors of cells or tissues.
KW - Angiogenesis
KW - Cancer
KW - Cell morphology
KW - Cell proliferation
KW - Oxygen
KW - ROS
KW - Senescence
UR - http://www.scopus.com/inward/record.url?scp=85162970683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85162970683&partnerID=8YFLogxK
U2 - 10.1007/s10561-023-10099-9
DO - 10.1007/s10561-023-10099-9
M3 - Article
C2 - 37365484
AN - SCOPUS:85162970683
SN - 1389-9333
VL - 25
SP - 195
EP - 215
JO - Cell and Tissue Banking
JF - Cell and Tissue Banking
IS - 1
ER -