The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

Cristian A. Hernandez; Eliseo A. Eugenin

doi:10.1016/j.coph.2023.102404

The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

Cristian A. Hernandez, Eliseo A. Eugenin

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.

Original language	English (US)
Article number	102404
Journal	Current Opinion in Pharmacology
Volume	73
DOIs	https://doi.org/10.1016/j.coph.2023.102404
State	Published - Dec 2023

Keywords

ATP
COVID-19
Connexin
Gap junctions
Hemichannels
NeuroHIV

ASJC Scopus subject areas

Pharmacology
Drug Discovery

Access to Document

10.1016/j.coph.2023.102404

Cite this

@article{289c382b1a28425eb06cbd0656408047,

title = "The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2",

abstract = "Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.",

keywords = "ATP, COVID-19, Connexin, Gap junctions, Hemichannels, NeuroHIV",

author = "Hernandez, {Cristian A.} and Eugenin, {Eliseo A.}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = dec,

doi = "10.1016/j.coph.2023.102404",

language = "English (US)",

volume = "73",

journal = "Current Opinion in Pharmacology",

issn = "1471-4892",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

AU - Hernandez, Cristian A.

AU - Eugenin, Eliseo A.

PY - 2023/12

Y1 - 2023/12

N2 - Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.

AB - Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.

KW - ATP

KW - COVID-19

KW - Connexin

KW - Gap junctions

KW - Hemichannels

KW - NeuroHIV

UR - http://www.scopus.com/inward/record.url?scp=85173079870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85173079870&partnerID=8YFLogxK

U2 - 10.1016/j.coph.2023.102404

DO - 10.1016/j.coph.2023.102404

M3 - Review article

C2 - 37734241

AN - SCOPUS:85173079870

SN - 1471-4892

VL - 73

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

M1 - 102404

ER -

The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this