The role of placental carbonyl reducing enzymes in biotransformation of bupropion and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone

Keyphrases

• Biotransformation 100%
• Bupropion 100%
• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 100%
• Carbonyl Reducing Enzymes 100%
• Placenta 36%
• Carbonyl Reductase 36%
• Reductive Metabolism 27%
• Cigarette Smoking 18%
• Subcellular Fractions 18%
• Cytosolic Fraction 18%
• Maternal Prenatal Smoking 18%
• Pharmacotherapy 9%
• Carcinogen 9%
• Pregnant Smokers 9%
• Smoking Cessation during Pregnancy 9%
• Smokers 9%
• Heavy Smokers 9%
• High Concentration 9%
• Detoxification 9%
• Drug Interactions 9%
• Continuous Exposure 9%
• Non-smokers 9%
• Cigarettes per Day 9%
• Nonsmoking Women 9%
• Carbonyl Reduction 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Bupropion 100%
• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanone 100%
• Nicotine-Derived Nitrosamine Ketone 81%
• Carbonyl Reductase 36%
• Cigarette Smoke 18%
• Pharmacotherapy 9%
• Carcinogen 9%
• Detoxication 9%
• Drug-Drug Interaction 9%
• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanol 9%