The role of serotonin in the actions of psychostimulants: molecular and pharmacological analyses

Kathryn A. Cunningham; Charles W. Bradberry; Albert S. Chang; Maarten E.A. Reith

doi:10.1016/0166-4328(96)00077-0

The role of serotonin in the actions of psychostimulants: molecular and pharmacological analyses

Kathryn A. Cunningham, Charles W. Bradberry, Albert S. Chang, Maarten E.A. Reith

Pharmacology & Toxicology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Cocaine is a highly abused psychostimulant which is a local anesthetic and inhibitor of the reuptake of dopamine (DA), serotonin (5-HT) and norepinephrine (NE). This manuscript details a brief summary and the primary conclusions of several presentations geared to present recent pharmacological analyses of the interaction of cocaine with 5-HT systems. These data illustrate the complexity of actions for cocaine in the brain and emphasize that, to fully understand the mechanisms which underlie its potent behavioural effects, the impact of this drug on 5-HT function as well as the interactions between 5-HT and the function of DA mesolimbic pathways must be considered.

Original language	English (US)
Pages (from-to)	93-102
Number of pages	10
Journal	Behavioural Brain Research
Volume	73
Issue number	1-2
DOIs	https://doi.org/10.1016/0166-4328(96)00077-0
State	Published - Dec 15 1995

Keywords

5-Hydroxytryptamine (5-HT)
Cocaine
Dopamine
Electrophysiology
Microdialysis
Neurochemistry
Reuptake
Serotonin
Steroid

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/0166-4328(96)00077-0

Cite this

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abstract = "Cocaine is a highly abused psychostimulant which is a local anesthetic and inhibitor of the reuptake of dopamine (DA), serotonin (5-HT) and norepinephrine (NE). This manuscript details a brief summary and the primary conclusions of several presentations geared to present recent pharmacological analyses of the interaction of cocaine with 5-HT systems. These data illustrate the complexity of actions for cocaine in the brain and emphasize that, to fully understand the mechanisms which underlie its potent behavioural effects, the impact of this drug on 5-HT function as well as the interactions between 5-HT and the function of DA mesolimbic pathways must be considered.",

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AU - Bradberry, Charles W.

AU - Chang, Albert S.

AU - Reith, Maarten E.A.

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KW - Dopamine

KW - Electrophysiology

KW - Microdialysis

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KW - Steroid

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The role of serotonin in the actions of psychostimulants: molecular and pharmacological analyses

Abstract

Keywords

ASJC Scopus subject areas

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