The Role of Skin Substitutes in Acute Burn and Reconstructive Burn Surgery: An Updated Comprehensive Review

Alen Palackic, Robert P. Duggan, Matthew S. Campbell, Elliot Walters, Ludwik K. Branski, Amina El Ayadi, Steven E. Wolf

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Burns disrupt the protective skin barrier with consequent loss of cutaneous temperature regulation, infection prevention, evaporative losses, and other vital functions. Chronically, burns lead to scarring, contractures, pain, and impaired psychosocial well-being. Several skin substitutes are available and replace the skin and partially restore functional outcomes and improve cosmesis. We performed a literature review to update readers on biologic and synthetic skin substitutes to date applied in acute and reconstructive burn surgery. Improvement has been rapid in the development of skin substitutes in the last decade; however, no available skin substitute fulfills criteria as a perfect replacement for damaged skin.

Original languageEnglish (US)
Pages (from-to)33-42
Number of pages10
JournalSeminars in Plastic Surgery
Volume36
Issue number1
DOIs
StatePublished - Feb 2022

Keywords

  • biologics
  • burns
  • epithelization
  • skin
  • synthetic dressing
  • total body surface area

ASJC Scopus subject areas

  • Surgery

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