The role of Src family kinases in the normal and neoplastic gastrointestinal tract

N. Banker, B. M. Evers, Mark Hellmich, Courtney Townsend

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalSurgical Oncology
Volume5
Issue number5-6
StatePublished - 1996

Fingerprint

src-Family Kinases
Gastrointestinal Tract
Hematopoietic System
Gastrointestinal Neoplasms
Protein-Tyrosine Kinases
Colonic Neoplasms
Nervous System
Signal Transduction
Growth
Proteins

Keywords

  • Differentiation
  • Gastrointestinal tract
  • Growth
  • Neoplasms
  • SH2
  • Src kinase

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

The role of Src family kinases in the normal and neoplastic gastrointestinal tract. / Banker, N.; Evers, B. M.; Hellmich, Mark; Townsend, Courtney.

In: Surgical Oncology, Vol. 5, No. 5-6, 1996, p. 201-210.

Research output: Contribution to journalArticle

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