The role of the invariant chain in mucosal immunity

Carlos A. Barrera, Ruben J. Almanza, Pearay L. Ogra, Victor Reyes

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The invariant chain (Ii) due to its intimate association with major histocompatibility complex (MHC) α and β chains is a determining element in the development of immune responses. Ii plays a major role in the assembly, the intracellular transport and peptide selection by class II MHC. A segment of Ii designated as CLIP (class II-associated Ii peptide) binds into the antigen binding site of class II MHC molecules until class II MHC reach intracellular compartments that contain peptides from internalized antigens. This association limits the self endogenous peptides that can bind to class II MHC molecules. The removal of CLIP from class II MHC catalyzes the binding of antigenic peptides and their subsequent cell surface expression. An isoform of Ii, known as chondroitin sulfate-modified Ii (IiCS), that is surface-expressed enhances T cell activation while acting as a coreceptor for CD44. The expression of class II MHC molecules by mucosal epithelial cells has generated interest in the role that these cells may have in mucosal immunity. Since in classical antigen-presenting cells (APC) the biology of class II MHC is regulated by Ii, it is necessary to bring into perspective the known functions of Ii in conventional APC to understand the role that Ii may play in mucosal epithelial cells as potential regulators of local immune responses.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalInternational Archives of Allergy and Immunology
Volume117
Issue number2
DOIs
StatePublished - Oct 1998

Fingerprint

Mucosal Immunity
Major Histocompatibility Complex
Peptides
Antigen-Presenting Cells
Epithelial Cells
Antigens
invariant chain
Chondroitin Sulfates
Cell Biology
Protein Isoforms
Binding Sites
T-Lymphocytes

Keywords

  • Antigen presenting cells
  • Class II MHC
  • Invariant chain
  • Mucosal immunity
  • T cell activation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The role of the invariant chain in mucosal immunity. / Barrera, Carlos A.; Almanza, Ruben J.; Ogra, Pearay L.; Reyes, Victor.

In: International Archives of Allergy and Immunology, Vol. 117, No. 2, 10.1998, p. 85-93.

Research output: Contribution to journalArticle

Barrera, Carlos A. ; Almanza, Ruben J. ; Ogra, Pearay L. ; Reyes, Victor. / The role of the invariant chain in mucosal immunity. In: International Archives of Allergy and Immunology. 1998 ; Vol. 117, No. 2. pp. 85-93.
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