The role of ThinPrep cytology in the investigation of lung tumors

P. Konofaos, P. Tomos, K. Malagari, A. Karakatsani, D. Pavlopoulos, E. Lachanas, M. Flessas, A. Kostakis, P. Karakitsos

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Aims of the study: The aim of this study was to evaluate the role of liquid-based cytology with the ThinPrep (TP) (Cytyc; Cytyc, Co, Boxborough, MA, USA) technique, using fine-needle aspiration (FNA) for sampling, in the investigation of suspicious pulmonary lesions. Methods: We performed percutaneous computed tomography (CT)-guided FNA biopsy of focal pulmonary lesions in 80 adult patients. Study subjects were all consecutive patients and potential candidates for surgery. The sample was then examined by both conventional smears (CS) and TP techniques. TP smears of all FNA were prepared from needle rinsing obtained following preparation of CS. All cytological diagnoses were correlated with the CS and/or thoracotomy histological diagnoses in order to evaluate the role of liquid-based cytology with the TP technique. Results: Using TP technique diagnosis was successfully established in 75 patients out of 80, whereas using CS cytology diagnosis was established in 54 patients (p<0.001, z=3899). Inadequate material was observed in 5 cases (6.25%) with the TP technique and in 13 cases (16.25%) with the CS technique (z=-2.77, p<0.05). Conclusions: We believe that the TP technique has a good overall yield for the diagnosis of suspicious for malignant lung lesions. We found that the accuracy of determining lung cancer was excellent.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalSurgical oncology
Issue number3
StatePublished - Nov 2006
Externally publishedYes


  • Biopsy
  • Lung cancer
  • Lung cancer diagnosis and staging
  • ThinPrep cytology

ASJC Scopus subject areas

  • Surgery
  • Oncology


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