The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus

A review of published field and laboratory studies

Aysen Gargili, Agustin Estrada-Peña, Jessica R. Spengler, Alexander Lukashev, Patricia A. Nuttall, Dennis Bente

    Research output: Contribution to journalReview article

    20 Citations (Scopus)

    Abstract

    This manuscript is part of a series of reviews that aim to cover published research on Crimean-Congo hemorrhagic fever (CCHF) and its etiological agent, CCHF virus (CCHFV). The virus is maintained and transmitted in a vertical and horizontal transmission cycle involving a variety of wild and domestic vertebrate species that act as amplification hosts, without showing signs of illness. These vertebrates have traditionally been considered reservoirs of CCHFV, but in fact they develop only a transient viremia, while the virus can persist in ticks for their entire lifespan, and can also be transmitted vertically to the next generation. As a result, ticks are now considered to be both the vector and the reservoir for the virus. CCHFV has been detected in a wide range of tick species, but only a few have been proven to be vectors and reservoirs, mainly because most published studies have been performed under a broad variety of conditions, precluding definitive characterization. This article reviews the published literature, summarizes current knowledge of the role of ticks in CCHFV maintenance and transmission and provides guidance for how to fill the knowledge gaps. Special focus is given to existing data on tick species in which vertical passage has been demonstrated under natural or experimental conditions. At the same time, we identify earlier reports that used unreliable methods and perceptions to ascribe a vector role to some species of ticks, and have contributed to confusion regarding viral transmission. We also examine epidemiological pathways of CCHFV circulation and discuss priority areas for future research.

    Original languageEnglish (US)
    Pages (from-to)93-119
    Number of pages27
    JournalAntiviral Research
    Volume144
    DOIs
    StatePublished - Aug 1 2017

    Fingerprint

    Crimean-Congo hemorrhagic fever virus
    Ticks
    Maintenance
    Viruses
    Vertebrates
    Crimean Hemorrhagic Fever
    Congo
    Viremia

    ASJC Scopus subject areas

    • Pharmacology
    • Virology

    Cite this

    The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus : A review of published field and laboratory studies. / Gargili, Aysen; Estrada-Peña, Agustin; Spengler, Jessica R.; Lukashev, Alexander; Nuttall, Patricia A.; Bente, Dennis.

    In: Antiviral Research, Vol. 144, 01.08.2017, p. 93-119.

    Research output: Contribution to journalReview article

    Gargili, Aysen ; Estrada-Peña, Agustin ; Spengler, Jessica R. ; Lukashev, Alexander ; Nuttall, Patricia A. ; Bente, Dennis. / The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus : A review of published field and laboratory studies. In: Antiviral Research. 2017 ; Vol. 144. pp. 93-119.
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