The role of vasopressin and the vasopressin type V1a receptor agonist selepressin in septic shock

Antonio Saad, Marc O. Maybauer

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Septic shock remains one of the major causes of morbidity and mortality in the critically ill. Despite early goal therapy and administration of cathecholaminergic agents, up to 30% of patients succumb to the disease. In this manuscript, we first summarize the standard of care of patients with septic shock and current guidelines. We review the physiologic role of vasopressin and its role in septic shock management. We then review the most up-to-date evidence on the potential role of V1a receptor agonists such as Selepressin, in septic shock. Exciting new trials are being completed in order to elucidate the role of V1a receptor agonists as potential first-line vasopressor alternatives in the therapy of circulatory shock in septic patients.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalJournal of Critical Care
Volume40
DOIs
StatePublished - Aug 1 2017

Fingerprint

Vasopressin Receptors
Septic Shock
Vasopressins
Standard of Care
Complementary Therapies
Secondary Prevention
Critical Illness
Guidelines
Morbidity
Mortality

Keywords

  • Catecholamine
  • FE201258
  • Norepinephrine
  • Sepsis
  • Terlipressin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

The role of vasopressin and the vasopressin type V1a receptor agonist selepressin in septic shock. / Saad, Antonio; Maybauer, Marc O.

In: Journal of Critical Care, Vol. 40, 01.08.2017, p. 41-45.

Research output: Contribution to journalReview article

@article{7eeef9ed1c2446558fbb760c6052fd0a,
title = "The role of vasopressin and the vasopressin type V1a receptor agonist selepressin in septic shock",
abstract = "Septic shock remains one of the major causes of morbidity and mortality in the critically ill. Despite early goal therapy and administration of cathecholaminergic agents, up to 30{\%} of patients succumb to the disease. In this manuscript, we first summarize the standard of care of patients with septic shock and current guidelines. We review the physiologic role of vasopressin and its role in septic shock management. We then review the most up-to-date evidence on the potential role of V1a receptor agonists such as Selepressin, in septic shock. Exciting new trials are being completed in order to elucidate the role of V1a receptor agonists as potential first-line vasopressor alternatives in the therapy of circulatory shock in septic patients.",
keywords = "Catecholamine, FE201258, Norepinephrine, Sepsis, Terlipressin",
author = "Antonio Saad and Maybauer, {Marc O.}",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.jcrc.2017.03.008",
language = "English (US)",
volume = "40",
pages = "41--45",
journal = "Journal of Critical Care",
issn = "0883-9441",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - The role of vasopressin and the vasopressin type V1a receptor agonist selepressin in septic shock

AU - Saad, Antonio

AU - Maybauer, Marc O.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Septic shock remains one of the major causes of morbidity and mortality in the critically ill. Despite early goal therapy and administration of cathecholaminergic agents, up to 30% of patients succumb to the disease. In this manuscript, we first summarize the standard of care of patients with septic shock and current guidelines. We review the physiologic role of vasopressin and its role in septic shock management. We then review the most up-to-date evidence on the potential role of V1a receptor agonists such as Selepressin, in septic shock. Exciting new trials are being completed in order to elucidate the role of V1a receptor agonists as potential first-line vasopressor alternatives in the therapy of circulatory shock in septic patients.

AB - Septic shock remains one of the major causes of morbidity and mortality in the critically ill. Despite early goal therapy and administration of cathecholaminergic agents, up to 30% of patients succumb to the disease. In this manuscript, we first summarize the standard of care of patients with septic shock and current guidelines. We review the physiologic role of vasopressin and its role in septic shock management. We then review the most up-to-date evidence on the potential role of V1a receptor agonists such as Selepressin, in septic shock. Exciting new trials are being completed in order to elucidate the role of V1a receptor agonists as potential first-line vasopressor alternatives in the therapy of circulatory shock in septic patients.

KW - Catecholamine

KW - FE201258

KW - Norepinephrine

KW - Sepsis

KW - Terlipressin

UR - http://www.scopus.com/inward/record.url?scp=85020376308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020376308&partnerID=8YFLogxK

U2 - 10.1016/j.jcrc.2017.03.008

DO - 10.1016/j.jcrc.2017.03.008

M3 - Review article

C2 - 28319910

AN - SCOPUS:85020376308

VL - 40

SP - 41

EP - 45

JO - Journal of Critical Care

JF - Journal of Critical Care

SN - 0883-9441

ER -