The roles of base excision repair enzyme OGG1 in gene expression

Ruoxi Wang, Wenjing Hao, Lang Pan, Istvan Boldogh, Xueqing Ba

    Research output: Contribution to journalReview articlepeer-review

    16 Scopus citations

    Abstract

    Modifications of DNA strands and nucleobases—both induced and accidental—are associated with unfavorable consequences including loss or gain in genetic information and mutations. Therefore, DNA repair proteins have essential roles in keeping genome fidelity. Recently, mounting evidence supports that 8-oxoguanine (8-oxoG), one of the most abundant genomic base modifications generated by reactive oxygen and nitrogen species, along with its cognate repair protein 8-oxoguanine DNA glycosylase1 (OGG1), has distinct roles in gene expression through transcription modulation or signal transduction. Binding to 8-oxoG located in gene regulatory regions, OGG1 acts as a transcription modulator, which can control transcription factor homing, induce allosteric transition of G-quadruplex structure, or recruit chromatin remodelers. In addition, post-repair complex formed between OGG1 and its repair product-free 8-oxoG increases the levels of active small GTPases and induces downstream signaling cascades to trigger gene expressions. The present review discusses how cells exploit damaged guanine base(s) and the authentic repair protein to orchestrate a profile of various transcriptomes in redox-regulated biological processes.

    Original languageEnglish (US)
    Pages (from-to)3741-3750
    Number of pages10
    JournalCellular and Molecular Life Sciences
    Volume75
    Issue number20
    DOIs
    StatePublished - Oct 1 2018

    Keywords

    • DNA methylation
    • Epigenetic
    • Post-repair signaling
    • Transcription modulation

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Cellular and Molecular Neuroscience
    • Cell Biology

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