The establishment of Science Cafés has become a popular strategy to enhance informal yet instruction-oriented interaction between medical and scientific experts and members of the relevant local communities. The purpose of this chapter is to report on two significant findings of a mixed-methods evaluation of the SCI (Science and Communities Interact) Café. Method: The Clinical and Translational Science Award in the Institute for Translational Sciences at the University of Texas Medical Branch (UTMB) in Galveston established an SCI Café program in 2013 to enable local residents to engage in dialogs with clinicians and researchers regarding their scientific interests and health concerns. A mixed-methods approach was used to evaluate the program. Results: The essential experience of SCI Café (SC) is updating one’s knowledge of a topic. The primary comparative and analytical feature of SC participation is expertise. Expertise varies in terms of the social position of the participants: graduate student, university staff, engaged participant, topical participant, and curious participant.