The search for nucleoside/nucleotide analog inhibitors of dengue virus

Yen Liang Chen; Fumiaki Yokokawa; Pei Yong Shi

doi:10.1016/j.antiviral.2015.07.010

The search for nucleoside/nucleotide analog inhibitors of dengue virus

Yen Liang Chen, Fumiaki Yokokawa, Pei Yong Shi

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Abstract Nucleoside analogs represent the largest class of antiviral agents and have been actively pursued for potential therapy of dengue virus (DENV) infection. Early success in the treatment of human immunodeficiency virus (HIV) infection and the recent approval of sofosbuvir for chronic hepatitis C have provided proof of concept for this class of compounds in clinics. Here we review (i) nucleoside analogs with known anti-DENV activity; (ii) challenges of the nucleoside antiviral approach for dengue; and (iii) potential strategies to overcome these challenges. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

Original language	English (US)
Article number	3670
Pages (from-to)	12-19
Number of pages	8
Journal	Antiviral research
Volume	122
DOIs	https://doi.org/10.1016/j.antiviral.2015.07.010
State	Published - Aug 10 2015

Keywords

Antiviral therapy
Dengue virus
Monophosphate prodrug
Nucleoside analogs

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/j.antiviral.2015.07.010

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title = "The search for nucleoside/nucleotide analog inhibitors of dengue virus",

abstract = "Abstract Nucleoside analogs represent the largest class of antiviral agents and have been actively pursued for potential therapy of dengue virus (DENV) infection. Early success in the treatment of human immunodeficiency virus (HIV) infection and the recent approval of sofosbuvir for chronic hepatitis C have provided proof of concept for this class of compounds in clinics. Here we review (i) nucleoside analogs with known anti-DENV activity; (ii) challenges of the nucleoside antiviral approach for dengue; and (iii) potential strategies to overcome these challenges. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.",

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AU - Yokokawa, Fumiaki

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N2 - Abstract Nucleoside analogs represent the largest class of antiviral agents and have been actively pursued for potential therapy of dengue virus (DENV) infection. Early success in the treatment of human immunodeficiency virus (HIV) infection and the recent approval of sofosbuvir for chronic hepatitis C have provided proof of concept for this class of compounds in clinics. Here we review (i) nucleoside analogs with known anti-DENV activity; (ii) challenges of the nucleoside antiviral approach for dengue; and (iii) potential strategies to overcome these challenges. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

AB - Abstract Nucleoside analogs represent the largest class of antiviral agents and have been actively pursued for potential therapy of dengue virus (DENV) infection. Early success in the treatment of human immunodeficiency virus (HIV) infection and the recent approval of sofosbuvir for chronic hepatitis C have provided proof of concept for this class of compounds in clinics. Here we review (i) nucleoside analogs with known anti-DENV activity; (ii) challenges of the nucleoside antiviral approach for dengue; and (iii) potential strategies to overcome these challenges. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

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KW - Monophosphate prodrug

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The search for nucleoside/nucleotide analog inhibitors of dengue virus

Abstract

Keywords

ASJC Scopus subject areas

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