The secreted g protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement

Alexander Bukreyev, Lijuan Yang, Peter L. Collins

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restriction in vivo, and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.

Original languageEnglish (US)
Pages (from-to)10880-10884
Number of pages5
JournalJournal of Virology
Volume86
Issue number19
DOIs
StatePublished - Oct 2012

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Human respiratory syncytial virus
complement
macrophages
Macrophages
neutralization
antibodies
Antibodies
antigens
Antigens
viruses
Proteins
Respiratory Syncytial Viruses
Fc Receptors
proteins
Alveolar Macrophages
Antiviral Agents
neutrophils
glycoproteins
leukocytes
Neutrophils

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

The secreted g protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement. / Bukreyev, Alexander; Yang, Lijuan; Collins, Peter L.

In: Journal of Virology, Vol. 86, No. 19, 10.2012, p. 10880-10884.

Research output: Contribution to journalArticle

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