The secreted g protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement

Alexander Bukreyev, Lijuan Yang, Peter L. Collins

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restriction in vivo, and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.

Original languageEnglish (US)
Pages (from-to)10880-10884
Number of pages5
JournalJournal of virology
Volume86
Issue number19
DOIs
StatePublished - Oct 1 2012

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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