Abstract
The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restriction in vivo, and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10880-10884 |
| Number of pages | 5 |
| Journal | Journal of virology |
| Volume | 86 |
| Issue number | 19 |
| DOIs | |
| State | Published - Oct 2012 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology
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