The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats

James Kasper, Rajiv Tikamdas, Myong Sang Kim, Kaley Macfadyen, Richard Aramini, Joseph Ladd, Sarah Bisceglia, Raymond Booth, Joanna Peris

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Serotonin (5-HT) 5-HT2C receptor agonists have shown promise as novel alcoholism pharmacotherapies, but developing selective agonists has been problematic. Female Sprague Dawley rats were given ethanol in a palatable gel vehicle during operant sessions. 5-HT2C receptor modulators (Ro60-0175, SB242,084, and (-)-trans-PAT) were administered before operant sessions. As a control for the effects of 5-HT2C receptor agonism on caloric intake, drugs were also tested using non-ethanol containing gelatin. Ro60-0175, a 5-HT2 family receptor agonist, decreased both ethanol and vehicle responding while (-)-trans-PAT, a 5-HT2C receptor agonist with 5-HT2A-2B receptor inverse agonist activity, selectively reduced only ethanol responding. The effect of 5-HT2C receptor agonists on self-administration after reinstatement of ethanol after a three week deprivation was also determined. (-)-trans-PAT eliminated increases in ethanol intake following ethanol deprivation whereas Ro60-0175 had no effect. These results emphasize the need for caloric controls and further support the idea that selective modulation of 5-HT2 family receptors is a potential pharmacotherapeutic approach in the treatment of alcoholism.

Original languageEnglish (US)
Pages (from-to)98-104
Number of pages7
JournalEuropean Journal of Pharmacology
Volume718
Issue number1-3
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Serotonin 5-HT2 Receptors
Receptor, Serotonin, 5-HT2C
Ethanol
Serotonin 5-HT2 Receptor Agonists
Alcoholism
Serotonin
Receptor, Serotonin, 5-HT2A
Self Administration
Gelatin
Energy Intake
Sprague Dawley Rats
1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene
Gels
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Alcohol deprivation
  • Alcoholism
  • Ethanol
  • Operant self-administration
  • Serotonin 2C receptor

ASJC Scopus subject areas

  • Pharmacology

Cite this

The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats. / Kasper, James; Tikamdas, Rajiv; Kim, Myong Sang; Macfadyen, Kaley; Aramini, Richard; Ladd, Joseph; Bisceglia, Sarah; Booth, Raymond; Peris, Joanna.

In: European Journal of Pharmacology, Vol. 718, No. 1-3, 2013, p. 98-104.

Research output: Contribution to journalArticle

Kasper, J, Tikamdas, R, Kim, MS, Macfadyen, K, Aramini, R, Ladd, J, Bisceglia, S, Booth, R & Peris, J 2013, 'The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats', European Journal of Pharmacology, vol. 718, no. 1-3, pp. 98-104. https://doi.org/10.1016/j.ejphar.2013.09.008
Kasper, James ; Tikamdas, Rajiv ; Kim, Myong Sang ; Macfadyen, Kaley ; Aramini, Richard ; Ladd, Joseph ; Bisceglia, Sarah ; Booth, Raymond ; Peris, Joanna. / The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats. In: European Journal of Pharmacology. 2013 ; Vol. 718, No. 1-3. pp. 98-104.
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