A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel

Translated title of the contribution: The severity of gestational diabetes mellitus affects microvascular dysfunction measured three years after pregnancy that may be related to increased oxidative stress

Eszter Mária Horváth, Rita Mágenheim, Beatrix Annamária Domján, Viktória Ferencz, Tímea Tänczer, Eszter Szabó, Rita Benko, Csaba Szabo, Ádám Tabák, Anikó Somogyi

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.

    Original languageHungarian
    Pages (from-to)1932-1936
    Number of pages5
    JournalOrvosi Hetilap
    Volume156
    Issue number47
    DOIs
    StatePublished - Nov 1 2015

    Fingerprint

    Gestational Diabetes
    Poly(ADP-ribose) Polymerases
    Oxidative Stress
    Pregnancy
    Blood Vessels
    Insulin
    Colorimetry
    Laser-Doppler Flowmetry
    Manometry
    Immunohistochemistry

    Keywords

    • Follow-up
    • Gestational diabetes
    • Oxidative stress
    • Vascular function

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel. / Horváth, Eszter Mária; Mágenheim, Rita; Domján, Beatrix Annamária; Ferencz, Viktória; Tänczer, Tímea; Szabó, Eszter; Benko, Rita; Szabo, Csaba; Tabák, Ádám; Somogyi, Anikó.

    In: Orvosi Hetilap, Vol. 156, No. 47, 01.11.2015, p. 1932-1936.

    Research output: Contribution to journalArticle

    Horváth, Eszter Mária ; Mágenheim, Rita ; Domján, Beatrix Annamária ; Ferencz, Viktória ; Tänczer, Tímea ; Szabó, Eszter ; Benko, Rita ; Szabo, Csaba ; Tabák, Ádám ; Somogyi, Anikó. / A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel. In: Orvosi Hetilap. 2015 ; Vol. 156, No. 47. pp. 1932-1936.
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    abstract = "Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.",
    keywords = "Follow-up, Gestational diabetes, Oxidative stress, Vascular function",
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    T1 - A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel

    AU - Horváth, Eszter Mária

    AU - Mágenheim, Rita

    AU - Domján, Beatrix Annamária

    AU - Ferencz, Viktória

    AU - Tänczer, Tímea

    AU - Szabó, Eszter

    AU - Benko, Rita

    AU - Szabo, Csaba

    AU - Tabák, Ádám

    AU - Somogyi, Anikó

    PY - 2015/11/1

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    N2 - Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.

    AB - Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.

    KW - Follow-up

    KW - Gestational diabetes

    KW - Oxidative stress

    KW - Vascular function

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