The significance of atypical nuclear changes in benign eccrine acrospiromas

A clinical and pathological study of 18 cases

Nobby Mambo

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A clinicopathologic study of 18 eccrine acrospiromas with atypical nuclear changes is presented. The changes included nuclear pleomorphism, prominent nucleoli, chromatin condensation, multinucleate giant cells and increased mitotic activity. Of the 5 neoplasms that recurred, 2 recurred once and were histologically and clinically benign, and the other 2 recurrences were histologically malignant. One neoplasm recurred twice, the first recurrence being histologically benign and the second histologically malignant. It is suggested that such nuclear atypias in otherwise clinically and histologically benign eccrine acrospiromas may be associated with local benign recurrences some of which may undergo malignant change. Search for these nuclear changes and long follow-up of patients in whom they occur are, therefore, recommended.

Original languageEnglish (US)
Pages (from-to)35-44
Number of pages10
JournalJournal of Cutaneous Pathology
Volume11
Issue number1
StatePublished - 1984
Externally publishedYes

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Acrospiroma
Recurrence
Giant Cells
Chromatin
Neoplasms
Clinical Studies

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

The significance of atypical nuclear changes in benign eccrine acrospiromas : A clinical and pathological study of 18 cases. / Mambo, Nobby.

In: Journal of Cutaneous Pathology, Vol. 11, No. 1, 1984, p. 35-44.

Research output: Contribution to journalArticle

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