The skinny on slug

Stephanie H. Shirley, Laurie G. Hudson, Jing He, Donna F. Kusewitt

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The zinc finger transcription factor Slug (Snai2) serves a wide variety of functions in the epidermis, with roles in skin development, hair growth, wound healing, skin cancer, and sunburn. Slug is expressed in basal keratinocytes and hair follicles where it is important in maintaining epidermal homeostasis. Slug also helps coordinate the skin response to exogenous stimuli. Slug is rapidly induced by a variety of growth factors and injurious agents and Slug controls, directly or indirectly, a variety of keratinocyte responses, including changes in differentiation, adhesion, motility, and production of inflammatory mediators. Slug thus modulates the interactions of the keratinocyte with its environment and with surrounding cells. The function of Slug in the epidermis appears to be distinct from that of the closely related Snail transcription factor.

Original languageEnglish (US)
Pages (from-to)851-861
Number of pages11
JournalMolecular Carcinogenesis
Volume49
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Skin
  • Skin neoplasms
  • Snail family transcription factors
  • Ultraviolet rays
  • Wound healing

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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