The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells

V. V. Dynnik, K. S. Grushin, A. F. Korystova, M. N. Nenov, A. N. Murashev, Yu M. Kokoz

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Abstract

In experiments on the rat cardiocytes it is shown that presence of arginine in cell incubation and secretion media stabilizes amplitude of basal L-type Ca2+ currents and decreases response variability under action of this current regulators. Response stabilization is determined by the balanced effect on L-channels of the secondary messengers cAMP and cGMP due to assisted by arginine activation of NO- and cGMP-involving reaction cascades. Under such conditions L-channel regulation with participation of PKG becomes more expressed, while generated by β-adrenoreceptor activation current is completely compensated by acetylcholine.

Original languageEnglish (US)
Pages (from-to)694-697
Number of pages4
JournalDoklady Akademii Nauk
Volume404
Issue number5
StatePublished - Dec 1 2005

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ASJC Scopus subject areas

  • General

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Dynnik, V. V., Grushin, K. S., Korystova, A. F., Nenov, M. N., Murashev, A. N., & Kokoz, Y. M. (2005). The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells. Doklady Akademii Nauk, 404(5), 694-697.