In experiments on the rat cardiocytes it is shown that presence of arginine in cell incubation and secretion media stabilizes amplitude of basal L-type Ca2+ currents and decreases response variability under action of this current regulators. Response stabilization is determined by the balanced effect on L-channels of the secondary messengers cAMP and cGMP due to assisted by arginine activation of NO- and cGMP-involving reaction cascades. Under such conditions L-channel regulation with participation of PKG becomes more expressed, while generated by β-adrenoreceptor activation current is completely compensated by acetylcholine.
|Original language||English (US)|
|Number of pages||4|
|Journal||Doklady Akademii Nauk|
|State||Published - Dec 1 2005|
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