The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells

V. V. Dynnik, K. S. Grushin, A. F. Korystova, M. N. Nenov, A. N. Murashev, Yu M. Kokoz

Research output: Contribution to journalArticle

Abstract

In experiments on the rat cardiocytes it is shown that presence of arginine in cell incubation and secretion media stabilizes amplitude of basal L-type Ca2+ currents and decreases response variability under action of this current regulators. Response stabilization is determined by the balanced effect on L-channels of the secondary messengers cAMP and cGMP due to assisted by arginine activation of NO- and cGMP-involving reaction cascades. Under such conditions L-channel regulation with participation of PKG becomes more expressed, while generated by β-adrenoreceptor activation current is completely compensated by acetylcholine.

Original languageEnglish (US)
Pages (from-to)694-697
Number of pages4
JournalDoklady Akademii Nauk
Volume404
Issue number5
StatePublished - 2005
Externally publishedYes

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Arginine
Acetylcholine

ASJC Scopus subject areas

  • General

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Dynnik, V. V., Grushin, K. S., Korystova, A. F., Nenov, M. N., Murashev, A. N., & Kokoz, Y. M. (2005). The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells. Doklady Akademii Nauk, 404(5), 694-697.

The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells. / Dynnik, V. V.; Grushin, K. S.; Korystova, A. F.; Nenov, M. N.; Murashev, A. N.; Kokoz, Yu M.

In: Doklady Akademii Nauk, Vol. 404, No. 5, 2005, p. 694-697.

Research output: Contribution to journalArticle

Dynnik, VV, Grushin, KS, Korystova, AF, Nenov, MN, Murashev, AN & Kokoz, YM 2005, 'The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells', Doklady Akademii Nauk, vol. 404, no. 5, pp. 694-697.
Dynnik VV, Grushin KS, Korystova AF, Nenov MN, Murashev AN, Kokoz YM. The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells. Doklady Akademii Nauk. 2005;404(5):694-697.
Dynnik, V. V. ; Grushin, K. S. ; Korystova, A. F. ; Nenov, M. N. ; Murashev, A. N. ; Kokoz, Yu M. / The stabilizing effect of Arg and NO in the regulation of L-type Ca2+ currents in cardiac cells. In: Doklady Akademii Nauk. 2005 ; Vol. 404, No. 5. pp. 694-697.
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AU - Kokoz, Yu M.

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