The strategies to reduce iron deficiency in blood donors randomized trial: Design, enrolment and early retention

W. Bialkowski, Barbara Bryant, K. S. Schlumpf, D. J. Wright, R. Birch, J. E. Kiss, P. D'Andrea, R. G. Cable, B. R. Spencer, V. Vij, A. E. Mast

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and Objectives: Repeated blood donation produces iron deficiency. Changes in dietary iron intake do not prevent donation-induced iron deficiency. Prolonging the interdonation interval or using oral iron supplements can mitigate donation-induced iron deficiency. The most effective operational methods for reducing iron deficiency in donors are unknown. Materials and Methods: 'Strategies To Reduce Iron Deficiency' (STRIDE) was a two-year, randomized, placebo-controlled study in blood donors. 692 donors were randomized into one of two educational groups or one of three interventional groups. Donors randomized to educational groups either received letters thanking them for donating, or, suggesting iron supplements or delayed donation if they had low ferritin. Donors randomized to interventional groups either received placebo, 19-mg or 38-mg iron pills. Results: Iron deficient erythropoiesis was present in 52·7% of males and 74·6% of females at enrolment. Adverse events within 60 days of enrolment were primarily mild gastrointestinal symptoms (64%). The incidence of de-enrolment within 60 days was more common in the interventional groups than in the educational groups (P = 0·002), but not more common in those receiving iron than placebo (P = 0·68). Conclusion: The prevalence of iron deficient erythropoiesis in donors enrolled in the STRIDE study is comparable to previously described cohorts of regular blood donors. De-enrolment within 60 days was higher for donors receiving tablets, although no more common in donors receiving iron than placebo.

Original languageEnglish (US)
Pages (from-to)178-185
Number of pages8
JournalVox Sanguinis
Volume108
Issue number2
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

Fingerprint

Blood Donors
Iron
Tissue Donors
Placebos
Erythropoiesis
Dietary Iron
Ferritins
Tablets

Keywords

  • Anaemia
  • Blood donation
  • Ferritin
  • Iron deficiency

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

Bialkowski, W., Bryant, B., Schlumpf, K. S., Wright, D. J., Birch, R., Kiss, J. E., ... Mast, A. E. (2015). The strategies to reduce iron deficiency in blood donors randomized trial: Design, enrolment and early retention. Vox Sanguinis, 108(2), 178-185. https://doi.org/10.1111/vox.12210

The strategies to reduce iron deficiency in blood donors randomized trial : Design, enrolment and early retention. / Bialkowski, W.; Bryant, Barbara; Schlumpf, K. S.; Wright, D. J.; Birch, R.; Kiss, J. E.; D'Andrea, P.; Cable, R. G.; Spencer, B. R.; Vij, V.; Mast, A. E.

In: Vox Sanguinis, Vol. 108, No. 2, 01.02.2015, p. 178-185.

Research output: Contribution to journalArticle

Bialkowski, W, Bryant, B, Schlumpf, KS, Wright, DJ, Birch, R, Kiss, JE, D'Andrea, P, Cable, RG, Spencer, BR, Vij, V & Mast, AE 2015, 'The strategies to reduce iron deficiency in blood donors randomized trial: Design, enrolment and early retention', Vox Sanguinis, vol. 108, no. 2, pp. 178-185. https://doi.org/10.1111/vox.12210
Bialkowski, W. ; Bryant, Barbara ; Schlumpf, K. S. ; Wright, D. J. ; Birch, R. ; Kiss, J. E. ; D'Andrea, P. ; Cable, R. G. ; Spencer, B. R. ; Vij, V. ; Mast, A. E. / The strategies to reduce iron deficiency in blood donors randomized trial : Design, enrolment and early retention. In: Vox Sanguinis. 2015 ; Vol. 108, No. 2. pp. 178-185.
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N2 - Background and Objectives: Repeated blood donation produces iron deficiency. Changes in dietary iron intake do not prevent donation-induced iron deficiency. Prolonging the interdonation interval or using oral iron supplements can mitigate donation-induced iron deficiency. The most effective operational methods for reducing iron deficiency in donors are unknown. Materials and Methods: 'Strategies To Reduce Iron Deficiency' (STRIDE) was a two-year, randomized, placebo-controlled study in blood donors. 692 donors were randomized into one of two educational groups or one of three interventional groups. Donors randomized to educational groups either received letters thanking them for donating, or, suggesting iron supplements or delayed donation if they had low ferritin. Donors randomized to interventional groups either received placebo, 19-mg or 38-mg iron pills. Results: Iron deficient erythropoiesis was present in 52·7% of males and 74·6% of females at enrolment. Adverse events within 60 days of enrolment were primarily mild gastrointestinal symptoms (64%). The incidence of de-enrolment within 60 days was more common in the interventional groups than in the educational groups (P = 0·002), but not more common in those receiving iron than placebo (P = 0·68). Conclusion: The prevalence of iron deficient erythropoiesis in donors enrolled in the STRIDE study is comparable to previously described cohorts of regular blood donors. De-enrolment within 60 days was higher for donors receiving tablets, although no more common in donors receiving iron than placebo.

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