The syntaxin family of vesicular transport receptors

Mark K. Bennett, JoséE Garcia-Arrarás, Lisa Elferink, Karen Peterson, Anne M. Fleming, Christopher D. Hazuka, Richard H. Scheller

Research output: Contribution to journalArticle

566 Citations (Scopus)

Abstract

Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on the cytoplasmic surface of cellular membranes. The syntaxins display a broad tissue distribution and, when expressed in COS cells, are targeted to different subcellular compartments. Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuroendocrine PC12 cells. These results indicate that the syntaxins are a family of receptors for intracellular transport vesicles and that each target membrane may be identified by a specific member of the syntaxin family.

Original languageEnglish (US)
Pages (from-to)863-873
Number of pages11
JournalCell
Volume74
Issue number5
DOIs
StatePublished - Sep 10 1993
Externally publishedYes

Fingerprint

Qa-SNARE Proteins
Syntaxin 1
Neurology
Nervous System
Membranes
Transport Vesicles
Neuroendocrine Cells
Proteins
Synaptic Vesicles
COS Cells
PC12 Cells
Microinjections
Tissue Distribution
Cell membranes
Anchors
Rats
Cell Membrane
Tissue
Calcium
Amino Acids

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Bennett, M. K., Garcia-Arrarás, J., Elferink, L., Peterson, K., Fleming, A. M., Hazuka, C. D., & Scheller, R. H. (1993). The syntaxin family of vesicular transport receptors. Cell, 74(5), 863-873. https://doi.org/10.1016/0092-8674(93)90466-4

The syntaxin family of vesicular transport receptors. / Bennett, Mark K.; Garcia-Arrarás, JoséE; Elferink, Lisa; Peterson, Karen; Fleming, Anne M.; Hazuka, Christopher D.; Scheller, Richard H.

In: Cell, Vol. 74, No. 5, 10.09.1993, p. 863-873.

Research output: Contribution to journalArticle

Bennett, MK, Garcia-Arrarás, J, Elferink, L, Peterson, K, Fleming, AM, Hazuka, CD & Scheller, RH 1993, 'The syntaxin family of vesicular transport receptors', Cell, vol. 74, no. 5, pp. 863-873. https://doi.org/10.1016/0092-8674(93)90466-4
Bennett MK, Garcia-Arrarás J, Elferink L, Peterson K, Fleming AM, Hazuka CD et al. The syntaxin family of vesicular transport receptors. Cell. 1993 Sep 10;74(5):863-873. https://doi.org/10.1016/0092-8674(93)90466-4
Bennett, Mark K. ; Garcia-Arrarás, JoséE ; Elferink, Lisa ; Peterson, Karen ; Fleming, Anne M. ; Hazuka, Christopher D. ; Scheller, Richard H. / The syntaxin family of vesicular transport receptors. In: Cell. 1993 ; Vol. 74, No. 5. pp. 863-873.
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