TY - JOUR
T1 - The syntaxin family of vesicular transport receptors
AU - Bennett, Mark K.
AU - Garcia-Arrarás, JoséE E.
AU - Elferink, Lisa A.
AU - Peterson, Karen
AU - Fleming, Anne M.
AU - Hazuka, Christopher D.
AU - Scheller, Richard H.
PY - 1993/9/10
Y1 - 1993/9/10
N2 - Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on the cytoplasmic surface of cellular membranes. The syntaxins display a broad tissue distribution and, when expressed in COS cells, are targeted to different subcellular compartments. Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuroendocrine PC12 cells. These results indicate that the syntaxins are a family of receptors for intracellular transport vesicles and that each target membrane may be identified by a specific member of the syntaxin family.
AB - Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on the cytoplasmic surface of cellular membranes. The syntaxins display a broad tissue distribution and, when expressed in COS cells, are targeted to different subcellular compartments. Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuroendocrine PC12 cells. These results indicate that the syntaxins are a family of receptors for intracellular transport vesicles and that each target membrane may be identified by a specific member of the syntaxin family.
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U2 - 10.1016/0092-8674(93)90466-4
DO - 10.1016/0092-8674(93)90466-4
M3 - Article
C2 - 7690687
AN - SCOPUS:0027328483
VL - 74
SP - 863
EP - 873
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -