The syntaxin family of vesicular transport receptors

Mark K. Bennett, JoséE E. Garcia-Arrarás, Lisa A. Elferink, Karen Peterson, Anne M. Fleming, Christopher D. Hazuka, Richard H. Scheller

Research output: Contribution to journalArticle

572 Scopus citations

Abstract

Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on the cytoplasmic surface of cellular membranes. The syntaxins display a broad tissue distribution and, when expressed in COS cells, are targeted to different subcellular compartments. Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuroendocrine PC12 cells. These results indicate that the syntaxins are a family of receptors for intracellular transport vesicles and that each target membrane may be identified by a specific member of the syntaxin family.

Original languageEnglish (US)
Pages (from-to)863-873
Number of pages11
JournalCell
Volume74
Issue number5
DOIs
StatePublished - Sep 10 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Bennett, M. K., Garcia-Arrarás, J. E., Elferink, L. A., Peterson, K., Fleming, A. M., Hazuka, C. D., & Scheller, R. H. (1993). The syntaxin family of vesicular transport receptors. Cell, 74(5), 863-873. https://doi.org/10.1016/0092-8674(93)90466-4