The Thr92AlaD2 polymorphism may play a novel role in hypothyroidism

Elizabeth A. McAninch; Antonio C. Bianco

doi:10.17925/use.2015.11.02.92

The Thr92AlaD2 polymorphism may play a novel role in hypothyroidism

Elizabeth A. McAninch, Antonio C. Bianco

Research output: Contribution to journal › Article › peer-review

Abstract

The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine "monotherapy." A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on "combination therapy" with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.

Original language	English (US)
Pages (from-to)	92-94
Number of pages	3
Journal	US Endocrinology
Volume	11
Issue number	2
DOIs	https://doi.org/10.17925/use.2015.11.02.92
State	Published - 2015
Externally published	Yes

Keywords

Deiodinase
Hypothyroidism
Levothyroxine
Polymorphism

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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10.17925/use.2015.11.02.92

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title = "The Thr92AlaD2 polymorphism may play a novel role in hypothyroidism",

abstract = "The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine {"}monotherapy.{"} A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on {"}combination therapy{"} with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.",

keywords = "Deiodinase, Hypothyroidism, Levothyroxine, Polymorphism",

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AB - The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine "monotherapy." A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on "combination therapy" with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.

KW - Deiodinase

KW - Hypothyroidism

KW - Levothyroxine

KW - Polymorphism

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JO - US Endocrinology

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The Thr92AlaD2 polymorphism may play a novel role in hypothyroidism

Abstract

Keywords

ASJC Scopus subject areas

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