The treatment of chronic constipation in adults: A systematic review

Sharon M. Tramonte, Michael B. Brand, Cynthia D. Mulrow, Mary G. Amato, Mary O'Keefe, Gilbert Ramirez

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate whether laxatives and fiber therapies improve symptoms and bowel movement frequency in adults with chronic constipation. DATA SOURCES: English language studies were identified from computerized MEDLINE (1966-1995). Biological Abstracts (1990-1995), and Micromedex searches; bibliographies; textbooks; laxative manufacturers; and experts. STUDY SELECTION: Randomized trials of laxative or fiber therapies lasting more than 1 week that evaluated clinical outcomes in adults with chronic constipation. MEASUREMENTS AND MAIN RESULTS: Two independent reviewers appraised each trial's characteristics including methodologic quality. There were 36 trials involving 1,815 persons from a variety of settings including clinics, hospitals and nursing homes. Twenty-three trials were 1 month or less in duration. Several laxative and fiber preparations were evaluated. Twenty trials had a placebo, usual care, or discontinuation of laxative control group, and 16 directly compared different agents. Laxatives and fiber increased bowel movement frequency by an overall weighted average of 1.4 (95% confidence interval [CI] 1.1-1.8) bowel movements per week. Fiber and bulk laxatives decreased abdominal pain and improved stool consistency compared with placebo. Most nonbulk laxative data concerning abdominal pain and stool consistency were inconclusive, though cisapride, lactulose, and lactitol improved consistency. Data concerning superiority of various treatments were inconclusive. No severe side effects for any of the therapies were reported. CONCLUSIONS: Both fiber and laxatives modestly improved bowel movement frequency in adults with chronic constipation. There was inadequate evidence to establish whether fiber was superior to laxatives or one laxative class was superior to another.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalJournal of General Internal Medicine
Volume12
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

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Laxatives
Constipation
Therapeutics
Abdominal Pain
Placebos
Cisapride
Lactulose
Textbooks
Bibliography
Nursing Homes
MEDLINE
Language
Confidence Intervals

Keywords

  • bowel movement
  • constipation
  • dietary fiber
  • frequency
  • laxatives
  • recta-analysis
  • treatment

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The treatment of chronic constipation in adults : A systematic review. / Tramonte, Sharon M.; Brand, Michael B.; Mulrow, Cynthia D.; Amato, Mary G.; O'Keefe, Mary; Ramirez, Gilbert.

In: Journal of General Internal Medicine, Vol. 12, No. 1, 1997, p. 15-24.

Research output: Contribution to journalArticle

Tramonte, Sharon M. ; Brand, Michael B. ; Mulrow, Cynthia D. ; Amato, Mary G. ; O'Keefe, Mary ; Ramirez, Gilbert. / The treatment of chronic constipation in adults : A systematic review. In: Journal of General Internal Medicine. 1997 ; Vol. 12, No. 1. pp. 15-24.
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