Abstract
Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 237-249 |
| Number of pages | 13 |
| Journal | Protein and Cell |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2011 |
Keywords
- Microtubule
- Protein-protein interaction
- RASSF1A
- Rap1A
- Vimentin
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Drug Discovery
- Cell Biology
Fingerprint Dive into the research topics of 'The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A'. Together they form a unique fingerprint.
Cite this
Verma, S. K., Ganesan, T. S., Kishore, U., & Parker, P. J. (2011). The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. Protein and Cell, 2(3), 237-249. https://doi.org/10.1007/s13238-011-1028-z