The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Sunil K. Verma, Trivadi S. Ganesan, Uday Kishore, Peter J. Parker

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

Original languageEnglish (US)
Pages (from-to)237-249
Number of pages13
JournalProtein and Cell
Volume2
Issue number3
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Monomeric GTP-Binding Proteins
Tumors
Association reactions
Biological Phenomena
Cell Adhesion
Microtubules
Embryonic Development
Neoplasms
Phosphorylation
Cell Proliferation
Cell proliferation
Adhesion

Keywords

  • Microtubule
  • Protein-protein interaction
  • Rap1A
  • RASSF1A
  • Vimentin

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Drug Discovery
  • Biochemistry

Cite this

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. / Verma, Sunil K.; Ganesan, Trivadi S.; Kishore, Uday; Parker, Peter J.

In: Protein and Cell, Vol. 2, No. 3, 2011, p. 237-249.

Research output: Contribution to journalArticle

Verma, SK, Ganesan, TS, Kishore, U & Parker, PJ 2011, 'The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A', Protein and Cell, vol. 2, no. 3, pp. 237-249. https://doi.org/10.1007/s13238-011-1028-z
Verma, Sunil K. ; Ganesan, Trivadi S. ; Kishore, Uday ; Parker, Peter J. / The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. In: Protein and Cell. 2011 ; Vol. 2, No. 3. pp. 237-249.
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