The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Sunil K. Verma, Trivadi S. Ganesan, Uday Kishore, Peter J. Parker

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

Original languageEnglish (US)
Pages (from-to)237-249
Number of pages13
JournalProtein and Cell
Volume2
Issue number3
DOIs
StatePublished - 2011
Externally publishedYes

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Keywords

  • Microtubule
  • Protein-protein interaction
  • Rap1A
  • RASSF1A
  • Vimentin

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Drug Discovery
  • Biochemistry

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