The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Sunil K. Verma; Trivadi S. Ganesan; Uday Kishore; Peter J. Parker

doi:10.1007/s13238-011-1028-z

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Sunil K. Verma, Trivadi S. Ganesan, Uday Kishore, Peter J. Parker

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

Original language	English (US)
Pages (from-to)	237-249
Number of pages	13
Journal	Protein and Cell
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/s13238-011-1028-z
State	Published - Mar 2011

Keywords

Microtubule
Protein-protein interaction
RASSF1A
Rap1A
Vimentin

ASJC Scopus subject areas

Biotechnology
Biochemistry
Drug Discovery
Cell Biology

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abstract = "Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.",

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AU - Kishore, Uday

AU - Parker, Peter J.

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AB - Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

KW - Microtubule

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KW - Rap1A

KW - Vimentin

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The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Abstract

Keywords

ASJC Scopus subject areas

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