The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly

Robert E. Barrow, Robert R. Wolfe, Mohan R. Dasu, Laura N. Barrow, David Herndon

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objective: The objective of this study was to test the hypothesis that hepatomegaly in burned children can be attenuated or reversed by blocking lipolysis and reducing free fatty acids delivered to the liver. Summary Background Data: Accelerated lipolysis in severely burned children has been shown to play an important role in the accumulation of hepatic TGs. Severely burned children who survive 10 days or more after injury commonly have enlarged livers often twice or more normal size for their sex, age, and weight. Methods: Ninety-eight children, 2 to 18 years of age, with burns covering more than 40% of their body surface and who received either propranolol (β-adrenergic blockade) or placebo were studied. Liver weights were measured by ultrasonic scanning. Body composition changes were identified by dual-image x-ray absorptiometry and validated by whole-body potassium-40 scintillation counting. Discarded abdominal cutaneous adipose tissue was collected before and after propranolol or placebo for microarray analysis. Results: In 80% of severely burned children studied not receiving propranolol, liver sizes increased by 100% or more while 86% of burned children receiving propranolol showed a decrease or no change in liver size over the same period of time after injury. Gene expression patterns of adipose tissue after propranolol treatment showed that all of the identified genes related to lipid metabolism were down-regulated. Conclusions: Data reported here support the hypothesis that β-adrenergic blockade can reduce delivery of fatty acids to the liver and hepatic congestion commonly found in severely burned children by inhibiting lipolysis and reducing hepatic blood flow.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalAnnals of Surgery
Volume243
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Hepatomegaly
Adrenergic Agents
Propranolol
Liver
Wounds and Injuries
Lipolysis
Placebos
Weights and Measures
Scintillation Counting
Abdominal Fat
Microarray Analysis
Body Composition
Burns
Lipid Metabolism
Nonesterified Fatty Acids
Ultrasonics
Adipose Tissue
Potassium
Fatty Acids
X-Rays

ASJC Scopus subject areas

  • Surgery

Cite this

Barrow, R. E., Wolfe, R. R., Dasu, M. R., Barrow, L. N., & Herndon, D. (2006). The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly. Annals of Surgery, 243(1), 115-120. https://doi.org/10.1097/01.sla.0000193834.07413.91

The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly. / Barrow, Robert E.; Wolfe, Robert R.; Dasu, Mohan R.; Barrow, Laura N.; Herndon, David.

In: Annals of Surgery, Vol. 243, No. 1, 01.2006, p. 115-120.

Research output: Contribution to journalArticle

Barrow, RE, Wolfe, RR, Dasu, MR, Barrow, LN & Herndon, D 2006, 'The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly', Annals of Surgery, vol. 243, no. 1, pp. 115-120. https://doi.org/10.1097/01.sla.0000193834.07413.91
Barrow, Robert E. ; Wolfe, Robert R. ; Dasu, Mohan R. ; Barrow, Laura N. ; Herndon, David. / The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly. In: Annals of Surgery. 2006 ; Vol. 243, No. 1. pp. 115-120.
@article{d0f617a7e9264a7a85a4e7dd8043fbda,
title = "The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly",
abstract = "Objective: The objective of this study was to test the hypothesis that hepatomegaly in burned children can be attenuated or reversed by blocking lipolysis and reducing free fatty acids delivered to the liver. Summary Background Data: Accelerated lipolysis in severely burned children has been shown to play an important role in the accumulation of hepatic TGs. Severely burned children who survive 10 days or more after injury commonly have enlarged livers often twice or more normal size for their sex, age, and weight. Methods: Ninety-eight children, 2 to 18 years of age, with burns covering more than 40{\%} of their body surface and who received either propranolol (β-adrenergic blockade) or placebo were studied. Liver weights were measured by ultrasonic scanning. Body composition changes were identified by dual-image x-ray absorptiometry and validated by whole-body potassium-40 scintillation counting. Discarded abdominal cutaneous adipose tissue was collected before and after propranolol or placebo for microarray analysis. Results: In 80{\%} of severely burned children studied not receiving propranolol, liver sizes increased by 100{\%} or more while 86{\%} of burned children receiving propranolol showed a decrease or no change in liver size over the same period of time after injury. Gene expression patterns of adipose tissue after propranolol treatment showed that all of the identified genes related to lipid metabolism were down-regulated. Conclusions: Data reported here support the hypothesis that β-adrenergic blockade can reduce delivery of fatty acids to the liver and hepatic congestion commonly found in severely burned children by inhibiting lipolysis and reducing hepatic blood flow.",
author = "Barrow, {Robert E.} and Wolfe, {Robert R.} and Dasu, {Mohan R.} and Barrow, {Laura N.} and David Herndon",
year = "2006",
month = "1",
doi = "10.1097/01.sla.0000193834.07413.91",
language = "English (US)",
volume = "243",
pages = "115--120",
journal = "Annals of Surgery",
issn = "0003-4932",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly

AU - Barrow, Robert E.

AU - Wolfe, Robert R.

AU - Dasu, Mohan R.

AU - Barrow, Laura N.

AU - Herndon, David

PY - 2006/1

Y1 - 2006/1

N2 - Objective: The objective of this study was to test the hypothesis that hepatomegaly in burned children can be attenuated or reversed by blocking lipolysis and reducing free fatty acids delivered to the liver. Summary Background Data: Accelerated lipolysis in severely burned children has been shown to play an important role in the accumulation of hepatic TGs. Severely burned children who survive 10 days or more after injury commonly have enlarged livers often twice or more normal size for their sex, age, and weight. Methods: Ninety-eight children, 2 to 18 years of age, with burns covering more than 40% of their body surface and who received either propranolol (β-adrenergic blockade) or placebo were studied. Liver weights were measured by ultrasonic scanning. Body composition changes were identified by dual-image x-ray absorptiometry and validated by whole-body potassium-40 scintillation counting. Discarded abdominal cutaneous adipose tissue was collected before and after propranolol or placebo for microarray analysis. Results: In 80% of severely burned children studied not receiving propranolol, liver sizes increased by 100% or more while 86% of burned children receiving propranolol showed a decrease or no change in liver size over the same period of time after injury. Gene expression patterns of adipose tissue after propranolol treatment showed that all of the identified genes related to lipid metabolism were down-regulated. Conclusions: Data reported here support the hypothesis that β-adrenergic blockade can reduce delivery of fatty acids to the liver and hepatic congestion commonly found in severely burned children by inhibiting lipolysis and reducing hepatic blood flow.

AB - Objective: The objective of this study was to test the hypothesis that hepatomegaly in burned children can be attenuated or reversed by blocking lipolysis and reducing free fatty acids delivered to the liver. Summary Background Data: Accelerated lipolysis in severely burned children has been shown to play an important role in the accumulation of hepatic TGs. Severely burned children who survive 10 days or more after injury commonly have enlarged livers often twice or more normal size for their sex, age, and weight. Methods: Ninety-eight children, 2 to 18 years of age, with burns covering more than 40% of their body surface and who received either propranolol (β-adrenergic blockade) or placebo were studied. Liver weights were measured by ultrasonic scanning. Body composition changes were identified by dual-image x-ray absorptiometry and validated by whole-body potassium-40 scintillation counting. Discarded abdominal cutaneous adipose tissue was collected before and after propranolol or placebo for microarray analysis. Results: In 80% of severely burned children studied not receiving propranolol, liver sizes increased by 100% or more while 86% of burned children receiving propranolol showed a decrease or no change in liver size over the same period of time after injury. Gene expression patterns of adipose tissue after propranolol treatment showed that all of the identified genes related to lipid metabolism were down-regulated. Conclusions: Data reported here support the hypothesis that β-adrenergic blockade can reduce delivery of fatty acids to the liver and hepatic congestion commonly found in severely burned children by inhibiting lipolysis and reducing hepatic blood flow.

UR - http://www.scopus.com/inward/record.url?scp=30144443589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30144443589&partnerID=8YFLogxK

U2 - 10.1097/01.sla.0000193834.07413.91

DO - 10.1097/01.sla.0000193834.07413.91

M3 - Article

VL - 243

SP - 115

EP - 120

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 1

ER -