The validation of the concept of endogenous depression. A family study approach

N. C. Andreasen, W. Scheftner, T. Reich, R. M. Hirschfeld, J. Endicott, M. B. Keller

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Depressive illnesses are subdivided into endogenous and nonendogenous types in psychiatry throughout the world. We used one method of validating this nosologic subdivision: the determination of the extent to which the disorder is familial. Rates of depression were examined in 2,942 first-degree relatives of 566 individuals diagnosed as having unipolar major depressive disorder. Because no single definition of endogenous depression is universally accepted, four different methods for defining endogenous depression were compared: the Newcastle Scale, the Research Diagnostic Criteria, DSM-III, and the definition of 'autonomous depression' proposed by investigators at Yale University (New Haven, Conn). In general, no matter which definition was used, the relatives of the patients with endogenous illness did not have higher rates of depressive illness than those of the nonendogenous group. The Newcastle Scale was the most sensitive in picking up familial transmission of recurrent unipolar depression. The results of this investigation suggest that longitudinal approaches should be added to cross-sectional approaches for the best definition of endogenous depression.

Original languageEnglish (US)
Pages (from-to)246-251
Number of pages6
JournalArchives of General Psychiatry
Volume43
Issue number3
StatePublished - 1986

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Depressive Disorder
Depression
Major Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Research Personnel
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Andreasen, N. C., Scheftner, W., Reich, T., Hirschfeld, R. M., Endicott, J., & Keller, M. B. (1986). The validation of the concept of endogenous depression. A family study approach. Archives of General Psychiatry, 43(3), 246-251.

The validation of the concept of endogenous depression. A family study approach. / Andreasen, N. C.; Scheftner, W.; Reich, T.; Hirschfeld, R. M.; Endicott, J.; Keller, M. B.

In: Archives of General Psychiatry, Vol. 43, No. 3, 1986, p. 246-251.

Research output: Contribution to journalArticle

Andreasen, NC, Scheftner, W, Reich, T, Hirschfeld, RM, Endicott, J & Keller, MB 1986, 'The validation of the concept of endogenous depression. A family study approach', Archives of General Psychiatry, vol. 43, no. 3, pp. 246-251.
Andreasen NC, Scheftner W, Reich T, Hirschfeld RM, Endicott J, Keller MB. The validation of the concept of endogenous depression. A family study approach. Archives of General Psychiatry. 1986;43(3):246-251.
Andreasen, N. C. ; Scheftner, W. ; Reich, T. ; Hirschfeld, R. M. ; Endicott, J. ; Keller, M. B. / The validation of the concept of endogenous depression. A family study approach. In: Archives of General Psychiatry. 1986 ; Vol. 43, No. 3. pp. 246-251.
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