The value of estrogen and progesterone receptor determinations in advanced breast cancer: Estrogen receptor level but not progesterone receptor level correlates with response to tamoxifen

W. R. Bezwoda, J. D. Esser, R. Dansey, I. Kessel, M. Lange

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Four hundred fifteen patients with metastatic breast cancer with known hormone receptor status received primary treatment with tamoxifen. Measured values for the estrogen receptor (ER, i.e., with estrogen binding) followed a continuous distribution (range, 3 to 1000 fmol/mg of protein). These values correlated positively with age. The response to treatment with tamoxifen correlated with the ER level, with response rates of approximately 80% when the ER level was greater than 30.1 fmol/mg of protein. Two hundred eighteen (218 of 415, 52%) patients had progesterone receptor (PR) values greater than 10 fmol/mg. The PR positivity correlated with the ER level. Patients with PR levels greater than 10 fmol/mg of protein (124 of 226, 55%) had a significantly higher response rate than those with values less than 10 fmol/mg of protein (45 of 189, 24%). However, in a multivariate analysis including both receptor levels, age, site, and number of metastases, only the ER level was significant in predicting the response to treatment with tamoxifen. A quantitative estimation of the ER level thus is the best predictor of response to hormonal treatment with tamoxifen for advanced breast cancer.

Original languageEnglish (US)
Pages (from-to)867-872
Number of pages6
JournalCancer
Volume68
Issue number4
StatePublished - 1991
Externally publishedYes

Fingerprint

Progesterone Receptors
Tamoxifen
Estrogen Receptors
Breast Neoplasms
Proteins
Therapeutics
Estrogens
Multivariate Analysis
Hormones
Neoplasm Metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The value of estrogen and progesterone receptor determinations in advanced breast cancer : Estrogen receptor level but not progesterone receptor level correlates with response to tamoxifen. / Bezwoda, W. R.; Esser, J. D.; Dansey, R.; Kessel, I.; Lange, M.

In: Cancer, Vol. 68, No. 4, 1991, p. 867-872.

Research output: Contribution to journalArticle

@article{2adf4f999e974f1d8975880f2c6f5f11,
title = "The value of estrogen and progesterone receptor determinations in advanced breast cancer: Estrogen receptor level but not progesterone receptor level correlates with response to tamoxifen",
abstract = "Four hundred fifteen patients with metastatic breast cancer with known hormone receptor status received primary treatment with tamoxifen. Measured values for the estrogen receptor (ER, i.e., with estrogen binding) followed a continuous distribution (range, 3 to 1000 fmol/mg of protein). These values correlated positively with age. The response to treatment with tamoxifen correlated with the ER level, with response rates of approximately 80{\%} when the ER level was greater than 30.1 fmol/mg of protein. Two hundred eighteen (218 of 415, 52{\%}) patients had progesterone receptor (PR) values greater than 10 fmol/mg. The PR positivity correlated with the ER level. Patients with PR levels greater than 10 fmol/mg of protein (124 of 226, 55{\%}) had a significantly higher response rate than those with values less than 10 fmol/mg of protein (45 of 189, 24{\%}). However, in a multivariate analysis including both receptor levels, age, site, and number of metastases, only the ER level was significant in predicting the response to treatment with tamoxifen. A quantitative estimation of the ER level thus is the best predictor of response to hormonal treatment with tamoxifen for advanced breast cancer.",
author = "Bezwoda, {W. R.} and Esser, {J. D.} and R. Dansey and I. Kessel and M. Lange",
year = "1991",
language = "English (US)",
volume = "68",
pages = "867--872",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - The value of estrogen and progesterone receptor determinations in advanced breast cancer

T2 - Estrogen receptor level but not progesterone receptor level correlates with response to tamoxifen

AU - Bezwoda, W. R.

AU - Esser, J. D.

AU - Dansey, R.

AU - Kessel, I.

AU - Lange, M.

PY - 1991

Y1 - 1991

N2 - Four hundred fifteen patients with metastatic breast cancer with known hormone receptor status received primary treatment with tamoxifen. Measured values for the estrogen receptor (ER, i.e., with estrogen binding) followed a continuous distribution (range, 3 to 1000 fmol/mg of protein). These values correlated positively with age. The response to treatment with tamoxifen correlated with the ER level, with response rates of approximately 80% when the ER level was greater than 30.1 fmol/mg of protein. Two hundred eighteen (218 of 415, 52%) patients had progesterone receptor (PR) values greater than 10 fmol/mg. The PR positivity correlated with the ER level. Patients with PR levels greater than 10 fmol/mg of protein (124 of 226, 55%) had a significantly higher response rate than those with values less than 10 fmol/mg of protein (45 of 189, 24%). However, in a multivariate analysis including both receptor levels, age, site, and number of metastases, only the ER level was significant in predicting the response to treatment with tamoxifen. A quantitative estimation of the ER level thus is the best predictor of response to hormonal treatment with tamoxifen for advanced breast cancer.

AB - Four hundred fifteen patients with metastatic breast cancer with known hormone receptor status received primary treatment with tamoxifen. Measured values for the estrogen receptor (ER, i.e., with estrogen binding) followed a continuous distribution (range, 3 to 1000 fmol/mg of protein). These values correlated positively with age. The response to treatment with tamoxifen correlated with the ER level, with response rates of approximately 80% when the ER level was greater than 30.1 fmol/mg of protein. Two hundred eighteen (218 of 415, 52%) patients had progesterone receptor (PR) values greater than 10 fmol/mg. The PR positivity correlated with the ER level. Patients with PR levels greater than 10 fmol/mg of protein (124 of 226, 55%) had a significantly higher response rate than those with values less than 10 fmol/mg of protein (45 of 189, 24%). However, in a multivariate analysis including both receptor levels, age, site, and number of metastases, only the ER level was significant in predicting the response to treatment with tamoxifen. A quantitative estimation of the ER level thus is the best predictor of response to hormonal treatment with tamoxifen for advanced breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=0025949343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025949343&partnerID=8YFLogxK

M3 - Article

C2 - 1855186

AN - SCOPUS:0025949343

VL - 68

SP - 867

EP - 872

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 4

ER -