Theoretical considerations for the efficient design of dna arrays

Arnold Vainrub, Tong Bin Li, Yuriy Fofanov, B. Montgomery Pettitt

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


The use of combinatorial or array-based detection (and synthesis) technologies has qualitatively changed many areas of bioscience in the last several years. These technologies include DNA, protein, and combinatorial chemistry arrays. Of these, DNA arrays, designed to determine gene content and expression levels in living cells, have shown the most potential. DNA arrays allow simultaneous, parallel measurement of thousands of interactions between target strands and genome-derived probes. Two areas of concern are the design and analysis of such experiments. Microarrays are rapidly producing enormous amounts of raw data. The bioinformatics solutions to problems associated with the analysis of data on this scale are a major current challenge. In addition, designing such experiments requires consideration of not only the genomic information required to answer a given problem but also consideration of the chemistry and physics of highly charged species near prepared surfaces.

Original languageEnglish (US)
Title of host publicationBiomedical Technology and Devices Handbook
PublisherCRC Press
ISBN (Electronic)9781439870716
ISBN (Print)9780849311406
StatePublished - Jan 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering
  • General Materials Science


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