Therapeutic considerations in treating depression in the elderly

D. L. Dunner, C. B. Montano, R. M.A. Hirschfeld, C. B. Nemeroff, C. L. DeVane

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The elderly depressed patient has a clinical picture unlike that of the younger individual. The pharmacokinetic profile, for example, changes in the normal aging process, which must be considered in choosing the proper antidepressant-and dosage - for an older person. Depressive illnesses are described in this review, with the focus on symptoms, prevalence, diagnosis, and treatment modalities. Cited are results of studies comparing tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs). Equivalent efficacy of the two classes of drugs was not unexpected. The higher degree of tolerability with SSRIs, however, should be of special interest to the clinician treating the elderly.

Original languageEnglish (US)
Pages (from-to)48-58
Number of pages11
JournalJournal of Clinical Psychiatry
Issue number12 SUPPL.
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Therapeutic considerations in treating depression in the elderly'. Together they form a unique fingerprint.

Cite this