Therapeutic Drug Monitoring in Pregnancy

Sarah C. Campbell; Laura M. Salisbury; Jessica K. Roberts; Manijeh Kamyar; Jeunesse Fredrickson; Maged M. Costantine; Catherine M.T. Sherwin

doi:10.1016/B978-0-12-802025-8.00008-8

Therapeutic Drug Monitoring in Pregnancy

Sarah C. Campbell, Laura M. Salisbury, Jessica K. Roberts, Manijeh Kamyar, Jeunesse Fredrickson, Maged M. Costantine, Catherine M.T. Sherwin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.

Original language	English (US)
Title of host publication	Clinical Challenges in Therapeutic Drug Monitoring
Subtitle of host publication	Special Populations, Physiological Conditions, and Pharmacogenomics
Publisher	Elsevier Inc.
Pages	185-211
Number of pages	27
ISBN (Electronic)	9780128020524
ISBN (Print)	9780128020258
DOIs	https://doi.org/10.1016/B978-0-12-802025-8.00008-8
State	Published - May 17 2016
Externally published	Yes

Keywords

Altered drug disposition
Anticonvulsants
Antidepressants
Cardiac drugs
Pregnancy

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-802025-8.00008-8

Cite this

Campbell, S. C., Salisbury, L. M., Roberts, J. K., Kamyar, M., Fredrickson, J., Costantine, M. M., & Sherwin, C. M. T. (2016). Therapeutic Drug Monitoring in Pregnancy. In Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions, and Pharmacogenomics (pp. 185-211). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802025-8.00008-8

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AU - Fredrickson, Jeunesse

AU - Costantine, Maged M.

AU - Sherwin, Catherine M.T.

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AB - During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.

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KW - Cardiac drugs

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BT - Clinical Challenges in Therapeutic Drug Monitoring

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ER -

Therapeutic Drug Monitoring in Pregnancy

Abstract

Keywords

ASJC Scopus subject areas

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