Therapeutic Drug Monitoring in Pregnancy

Sarah C. Campbell, Laura M. Salisbury, Jessica K. Roberts, Manijeh Kamyar, Jeunesse Fredrickson, Maged Costantine, Catherine M T Sherwin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

During pregnancy, important physiologic changes occur that affect pharmacokinetics and ultimately drug management. These include changes to renal and liver function, changes in serum protein levels, and the addition of a pharmacokinetic compartment (the infant and placenta) that is not present in the broader population. In addition, postpartum return to baseline physiology can further complicate drug management. This chapter examines therapeutic drug monitoring issues associated with pregnancy, including specific examples such as management of antidepressants.

Original languageEnglish (US)
Title of host publicationClinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions, and Pharmacogenomics
PublisherElsevier Inc.
Pages185-211
Number of pages27
ISBN (Electronic)9780128020524
ISBN (Print)9780128020258
DOIs
StatePublished - May 17 2016

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Keywords

  • Altered drug disposition
  • Anticonvulsants
  • Antidepressants
  • Cardiac drugs
  • Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Campbell, S. C., Salisbury, L. M., Roberts, J. K., Kamyar, M., Fredrickson, J., Costantine, M., & Sherwin, C. M. T. (2016). Therapeutic Drug Monitoring in Pregnancy. In Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions, and Pharmacogenomics (pp. 185-211). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802025-8.00008-8