Therapeutic factors secreted by mesenchymal stromal cells and tissue repair

Ryang Hwa Lee, Joo Youn Oh, Hosoon Choi, Nikolay Bazhanov

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long-term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases.

Original languageEnglish (US)
Pages (from-to)3073-3078
Number of pages6
JournalJournal of Cellular Biochemistry
Volume112
Issue number11
DOIs
StatePublished - Nov 1 2011

Keywords

  • ADULT PROGENITOR CELLS
  • MSCs
  • SECRETORY FACTORS

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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