Therapeutic potential of oridonin and its analogs

From anticancer and antiinflammation to neuroprotection

Jimin Xu, Eric A. Wold, Ye Ding, Qiang Shen, Jia Zhou

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.

Original languageEnglish (US)
Article number474
JournalMolecules
Volume23
Issue number2
DOIs
StatePublished - Jan 1 2018

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cancer
analogs
fibrosis
activity (biology)
medicine
East Asian Traditional Medicine
emerging
drugs
Herbal Medicine
Diterpenes
Drug Discovery
Structure-Activity Relationship
Bioactivity
Biological Products
Neoplasms
Fibrosis
Anti-Inflammatory Agents
Therapeutics
products
Liver

Keywords

  • Alzheimer’s disease
  • Anticancer
  • Antiinflammation
  • Neuroprotection
  • Oridonin

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Therapeutic potential of oridonin and its analogs : From anticancer and antiinflammation to neuroprotection. / Xu, Jimin; Wold, Eric A.; Ding, Ye; Shen, Qiang; Zhou, Jia.

In: Molecules, Vol. 23, No. 2, 474, 01.01.2018.

Research output: Contribution to journalReview article

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AB - Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.

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