Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Jimin Xu, Eric A. Wold, Ye Ding, Qiang Shen, Jia Zhou

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.

Original languageEnglish (US)
Article number474
JournalMolecules
Volume23
Issue number2
DOIs
StatePublished - Jan 1 2018

Keywords

  • Alzheimer’s disease
  • Anticancer
  • Antiinflammation
  • Neuroprotection
  • Oridonin

ASJC Scopus subject areas

  • Organic Chemistry

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