Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Jimin Xu; Eric A. Wold; Ye Ding; Qiang Shen; Jia Zhou

doi:10.3390/molecules23020474

Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Jimin Xu, Eric A. Wold, Ye Ding, Qiang Shen, Jia Zhou

Pharmacology & Toxicology

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.

Original language	English (US)
Article number	474
Journal	Molecules
Volume	23
Issue number	2
DOIs	https://doi.org/10.3390/molecules23020474
State	Published - 2018

Keywords

Alzheimer’s disease
Anticancer
Antiinflammation
Neuroprotection
Oridonin

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules23020474

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title = "Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection",

abstract = "Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.",

keywords = "Alzheimer{\textquoteright}s disease, Anticancer, Antiinflammation, Neuroprotection, Oridonin",

author = "Jimin Xu and Wold, {Eric A.} and Ye Ding and Qiang Shen and Jia Zhou",

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T1 - Therapeutic potential of oridonin and its analogs

T2 - From anticancer and antiinflammation to neuroprotection

AU - Xu, Jimin

AU - Wold, Eric A.

AU - Ding, Ye

AU - Shen, Qiang

AU - Zhou, Jia

PY - 2018

Y1 - 2018

N2 - Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.

AB - Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.

KW - Alzheimer’s disease

KW - Anticancer

KW - Antiinflammation

KW - Neuroprotection

KW - Oridonin

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DO - 10.3390/molecules23020474

M3 - Review article

C2 - 29470395

AN - SCOPUS:85042520156

SN - 1420-3049

VL - 23

JO - Molecules

JF - Molecules

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Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Abstract

Keywords

ASJC Scopus subject areas

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