Therapeutic Roles of Statins in Gynecology and Obstetrics

The Current Evidence

Burak Zeybek, Maged Costantine, Gokhan Kilic, Mostafa A. Borahay

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Introduction: Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase). The inhibition of mevalonate synthesis leads to subsequent inhibition of downstream products of this pathway, which explains the pleiotropic effects of these agents in addition to their well-known lipid-lowering effects. Accumulating evidence suggests that statins might be beneficial in various obstetric and gynecologic conditions. Methods: Literature searches were performed in PubMed and EMBASE for articles with content related to statins in obstetrics and gynecology. The findings are hereby reviewed and discussed. Results: Inhibition of mevalonate pathway leads to subsequent inhibition of downstream products such as geranyl pyrophosphate, farnesyl pyrophosphate, and geranylgeranyl pyrophosphate. These products are required for proper intracellular localization of several proteins, which play important roles in signaling pathways by regulating membrane trafficking, motility, proliferation, differentiation, and cytoskeletal organization. The pleiotropic effects of statins can be summarized in 4 categories: antiproliferative, anti-invasive, anti-inflammatory, and antiangiogenic. The growing body of evidence is promising for these agents to be beneficial in endometriosis, polycystic ovary syndrome, adhesion prevention, ovarian cancer, preeclampsia, and antiphospholipid syndrome. Although in vivo studies showed varying degrees of benefit on fibroids and preterm birth, appropriately designed clinical trials are needed to make definitive conclusions. Conclusion: Statins might play a role in the treatment of endometriosis, polycystic ovary syndrome, adhesion prevention, ovarian cancer, preeclampsia, and antiphospholipid syndrome.

Original languageEnglish (US)
Pages (from-to)802-817
Number of pages16
JournalReproductive Sciences
Volume25
Issue number6
DOIs
StatePublished - Jun 1 2018

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Gynecology
Obstetrics
Mevalonic Acid
Antiphospholipid Syndrome
Polycystic Ovary Syndrome
Endometriosis
Pre-Eclampsia
Ovarian Neoplasms
Therapeutics
Premature Birth
Leiomyoma
PubMed
Oxidoreductases
Anti-Inflammatory Agents
Cholesterol
Clinical Trials
Lipids
Membranes
Enzymes

Keywords

  • adhesion prevention
  • antiphospholipid syndrome
  • endometriosis
  • fibroids
  • gynecologic cancers
  • leiomyoma
  • polycystic ovary syndrome
  • preeclampsia
  • preterm birth
  • statins

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Therapeutic Roles of Statins in Gynecology and Obstetrics : The Current Evidence. / Zeybek, Burak; Costantine, Maged; Kilic, Gokhan; Borahay, Mostafa A.

In: Reproductive Sciences, Vol. 25, No. 6, 01.06.2018, p. 802-817.

Research output: Contribution to journalReview article

Zeybek, Burak ; Costantine, Maged ; Kilic, Gokhan ; Borahay, Mostafa A. / Therapeutic Roles of Statins in Gynecology and Obstetrics : The Current Evidence. In: Reproductive Sciences. 2018 ; Vol. 25, No. 6. pp. 802-817.
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