Therapy and prophylaxis of Ebola virus infections

Heinz Feldmann, Steven M. Jones, Hans Joachim Schnittler, Thomas Geisbert

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The first cases of Ebola hemorrhagic fever were reported from Sudan and Zaire (now Democratic Republic of the Congo) in 1976, but the virus has only received significant attention since 1995. Until recently, the development of therapeutics or vaccines was not considered a priority, The knowledge gained during the past decade on the biology and pathogenesis of Ebola virus has led to the development of therapeutic strategies that are currently being investigated. Considering the aggressive nature of Ebola infections, in particular the rapid and overwhelming viral burdens, early diagnosis will play a significant role in determining the success of any intervention strategy. Advanced understanding of the immune response has produced several vaccine candidates of which a few can be considered for further evaluation. This review will summarize and discuss the current therapeutic and prophylactic strategies for Ebola hemorrhagic fever.

Original languageEnglish (US)
Pages (from-to)823-830
Number of pages8
JournalCurrent Opinion in Investigational Drugs
Volume6
Issue number8
StatePublished - Aug 2005
Externally publishedYes

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Keywords

  • Ebola virus
  • Filoviridae
  • Pathogenesis
  • Prophylaxis
  • Replication
  • Therapy

ASJC Scopus subject areas

  • Pharmacology

Cite this

Feldmann, H., Jones, S. M., Schnittler, H. J., & Geisbert, T. (2005). Therapy and prophylaxis of Ebola virus infections. Current Opinion in Investigational Drugs, 6(8), 823-830.