Therapy of patients with head injuries

Key parameters for management

Donald Prough, John Lang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Secondary brain injury, presumed secondary to ischemia, increases the mortality and morbidity of traumatic brain injury. Although many mechanisms appear to be involved, many potential ischemic insults result from changes in readily observable physiologic variables. Methods: A focused search of scientific articles published in English to determine what data are available to suggest parameters within which key physiologic variables should be maintained. Results: Few data demonstrate that maintenance of variables within specific ranges alters outcome; however, considerable evidence establishes associations with poor outcome and hypotension, intracranial hypertension, and cerebral venous saturation. Key parameters vary somewhat based upon the phase of treatment after injury. Other variables, such as systemic oxygen delivery and brain saturation measured by near-infrared spectroscopy, are less well linked to outcome. Conclusions: Further research is necessary to establish that manipulation of physiologic variables to maintain them within preset ranges improves outcome.

Original languageEnglish (US)
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume42
Issue number5 SUPPL.
StatePublished - May 1997

Fingerprint

Intracranial Hypertension
Near-Infrared Spectroscopy
Craniocerebral Trauma
Hypotension
Brain Injuries
Ischemia
Maintenance
Oxygen
Morbidity
Mortality
Wounds and Injuries
Brain
Research
Therapeutics
Traumatic Brain Injury

ASJC Scopus subject areas

  • Surgery

Cite this

Therapy of patients with head injuries : Key parameters for management. / Prough, Donald; Lang, John.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 42, No. 5 SUPPL., 05.1997.

Research output: Contribution to journalArticle

@article{6891250a7bf14f638e37ad7b2df68a96,
title = "Therapy of patients with head injuries: Key parameters for management",
abstract = "Background: Secondary brain injury, presumed secondary to ischemia, increases the mortality and morbidity of traumatic brain injury. Although many mechanisms appear to be involved, many potential ischemic insults result from changes in readily observable physiologic variables. Methods: A focused search of scientific articles published in English to determine what data are available to suggest parameters within which key physiologic variables should be maintained. Results: Few data demonstrate that maintenance of variables within specific ranges alters outcome; however, considerable evidence establishes associations with poor outcome and hypotension, intracranial hypertension, and cerebral venous saturation. Key parameters vary somewhat based upon the phase of treatment after injury. Other variables, such as systemic oxygen delivery and brain saturation measured by near-infrared spectroscopy, are less well linked to outcome. Conclusions: Further research is necessary to establish that manipulation of physiologic variables to maintain them within preset ranges improves outcome.",
author = "Donald Prough and John Lang",
year = "1997",
month = "5",
language = "English (US)",
volume = "42",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "5 SUPPL.",

}

TY - JOUR

T1 - Therapy of patients with head injuries

T2 - Key parameters for management

AU - Prough, Donald

AU - Lang, John

PY - 1997/5

Y1 - 1997/5

N2 - Background: Secondary brain injury, presumed secondary to ischemia, increases the mortality and morbidity of traumatic brain injury. Although many mechanisms appear to be involved, many potential ischemic insults result from changes in readily observable physiologic variables. Methods: A focused search of scientific articles published in English to determine what data are available to suggest parameters within which key physiologic variables should be maintained. Results: Few data demonstrate that maintenance of variables within specific ranges alters outcome; however, considerable evidence establishes associations with poor outcome and hypotension, intracranial hypertension, and cerebral venous saturation. Key parameters vary somewhat based upon the phase of treatment after injury. Other variables, such as systemic oxygen delivery and brain saturation measured by near-infrared spectroscopy, are less well linked to outcome. Conclusions: Further research is necessary to establish that manipulation of physiologic variables to maintain them within preset ranges improves outcome.

AB - Background: Secondary brain injury, presumed secondary to ischemia, increases the mortality and morbidity of traumatic brain injury. Although many mechanisms appear to be involved, many potential ischemic insults result from changes in readily observable physiologic variables. Methods: A focused search of scientific articles published in English to determine what data are available to suggest parameters within which key physiologic variables should be maintained. Results: Few data demonstrate that maintenance of variables within specific ranges alters outcome; however, considerable evidence establishes associations with poor outcome and hypotension, intracranial hypertension, and cerebral venous saturation. Key parameters vary somewhat based upon the phase of treatment after injury. Other variables, such as systemic oxygen delivery and brain saturation measured by near-infrared spectroscopy, are less well linked to outcome. Conclusions: Further research is necessary to establish that manipulation of physiologic variables to maintain them within preset ranges improves outcome.

UR - http://www.scopus.com/inward/record.url?scp=0030976194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030976194&partnerID=8YFLogxK

M3 - Article

VL - 42

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 5 SUPPL.

ER -