Thermal property and assessment of biocompatibility of poly(lactic-co- glycolic) acid/graphene nanocomposites

Ananta R. Adhikari, Irene Rusakova, Ardebili Haleh, Jonathan Luisi, Neli I. Panova, Fernanda Laezza, Wei Kan Chu

Research output: Contribution to journalArticle

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Abstract

Polymer-matrix nanocomposites based on Poly(lactic-co-glycolic) acid (PLGA) and Graphene platelets (GNPs) were studied. GNPs, nanomaterials with a 2D flat surface, were chosen with or without chemical modification in PLGA/GNP nanocomposites and their microstructure, thermal property, and their compatibility as scaffolds for cell growth were investigated. PLGA/GNP nanocomposites (0, 1, and 5 wt. % of GNPs) were prepared using a solution based technique. Transmission electron microscopy, X-ray diffraction, Differential scanning calorimeter, and Thermogravimetric analyzer were used to analyze morphology and thermal properties. This work demonstrated the role of GNPs flat surface to provide a favorable platform resulting in an enhanced PLGA crystallization. Functionalized GNPs suppress both the thermal stability and the crystallization of PLGA. Finally, to determine the potential usefulness of these scaffolds for biomedical applications, mammalian cells were cultured on various PLGA/GNP nanocomposites (0, 1, and 5 wt. % GNPs). 1 wt. % PLGA/GNP nanocomposites showed better biocompatibility for cell growth with/without graphenes functionalization compared to pure PLGA and 5 wt. % PLGA/GNP. The function of GNPs in PLGA/GNPs (1 wt. %) composites is to provide a stage for PLGA crystallization where cell growth is favored. These results provide strong evidence for a new class of materials that could be important for biomedical applications.

Original languageEnglish (US)
Article number054701
JournalJournal of Applied Physics
Volume115
Issue number5
DOIs
StatePublished - 2014

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biocompatibility
platelets
nanocomposites
graphene
thermodynamic properties
acids
crystallization
flat surfaces
cultured cells
compatibility
calorimeters
analyzers
thermal stability
platforms

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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Thermal property and assessment of biocompatibility of poly(lactic-co- glycolic) acid/graphene nanocomposites. / Adhikari, Ananta R.; Rusakova, Irene; Haleh, Ardebili; Luisi, Jonathan; Panova, Neli I.; Laezza, Fernanda; Chu, Wei Kan.

In: Journal of Applied Physics, Vol. 115, No. 5, 054701, 2014.

Research output: Contribution to journalArticle

Adhikari, Ananta R. ; Rusakova, Irene ; Haleh, Ardebili ; Luisi, Jonathan ; Panova, Neli I. ; Laezza, Fernanda ; Chu, Wei Kan. / Thermal property and assessment of biocompatibility of poly(lactic-co- glycolic) acid/graphene nanocomposites. In: Journal of Applied Physics. 2014 ; Vol. 115, No. 5.
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