Thermocoagulation effect of diode laser radiation in the human prostate: Acute and chronic study

Mariela Pow-Sang, Daniel F. Cowan, Eduardo Orihuela, Richard Dyer, Massoud Motamedi, Michael M. Warren, Julio E. Pow-Sang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: To evaluate the safety and efficacy of low-power slow-heating diode laser-induced photocoagulation of prostatic tissue for treatment of benign prostatic hyperplasia, we conducted a series of acute and chronic studies using a diode laser (810 nm) to irradiate human prostate. Methods: The study included 6 patients undergoing radical prostatectomy because of malignancy. Laser radiation to the prostate was given transurethrally, in a noncontact mode, at the time of the procedure in 2 patients (acute group): 10 W for 300 seconds on the right side of the prostate and 15 W for 180 seconds on the left. In the remaining 4 patients (chronic group), laser radiation was given at 1, 7, 10, and 12 weeks prior to the prostatectomy. Results: In the acute group the average depth of coagulation was 8.5 and 9.0 mm for the laser regimens of 15 W for 180 seconds and the 10 W for 300 seconds, respectively. In the chronic group, the average depth of coagulation was 8.9 mm for both laser regimens studied. In the acute group, there was an ill-defined hemorrhagic ring at the periphery of the lesion. At 1 week, an intact necrotic coagulum was present. At 7 weeks, some of the coagulated tissue had already sloughed off. Longer follow-up at 10 and 12 weeks demonstrated formation of a well-defined cavity with mostly re-epithelialized surface. Conclusions: Our findings suggest that noncontact diode laser (810 nm) irradiation can induce in the human prostate significant coagulation necrosis followed by sloughing of tissue and cavitation of the prostatic urethra.

Original languageEnglish (US)
Pages (from-to)790-794
Number of pages5
JournalUrology
Volume45
Issue number5
DOIs
StatePublished - 1995

Fingerprint

Semiconductor Lasers
Electrocoagulation
Prostate
Lasers
Radiation
Prostatectomy
Light Coagulation
Prostatic Hyperplasia
Urethra
Heating
Necrosis
Safety
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Pow-Sang, M., Cowan, D. F., Orihuela, E., Dyer, R., Motamedi, M., Warren, M. M., & Pow-Sang, J. E. (1995). Thermocoagulation effect of diode laser radiation in the human prostate: Acute and chronic study. Urology, 45(5), 790-794. https://doi.org/10.1016/S0090-4295(99)80085-5

Thermocoagulation effect of diode laser radiation in the human prostate : Acute and chronic study. / Pow-Sang, Mariela; Cowan, Daniel F.; Orihuela, Eduardo; Dyer, Richard; Motamedi, Massoud; Warren, Michael M.; Pow-Sang, Julio E.

In: Urology, Vol. 45, No. 5, 1995, p. 790-794.

Research output: Contribution to journalArticle

Pow-Sang, M, Cowan, DF, Orihuela, E, Dyer, R, Motamedi, M, Warren, MM & Pow-Sang, JE 1995, 'Thermocoagulation effect of diode laser radiation in the human prostate: Acute and chronic study', Urology, vol. 45, no. 5, pp. 790-794. https://doi.org/10.1016/S0090-4295(99)80085-5
Pow-Sang, Mariela ; Cowan, Daniel F. ; Orihuela, Eduardo ; Dyer, Richard ; Motamedi, Massoud ; Warren, Michael M. ; Pow-Sang, Julio E. / Thermocoagulation effect of diode laser radiation in the human prostate : Acute and chronic study. In: Urology. 1995 ; Vol. 45, No. 5. pp. 790-794.
@article{8b072932a2834ebf9ef03efd4d0114bb,
title = "Thermocoagulation effect of diode laser radiation in the human prostate: Acute and chronic study",
abstract = "Objectives: To evaluate the safety and efficacy of low-power slow-heating diode laser-induced photocoagulation of prostatic tissue for treatment of benign prostatic hyperplasia, we conducted a series of acute and chronic studies using a diode laser (810 nm) to irradiate human prostate. Methods: The study included 6 patients undergoing radical prostatectomy because of malignancy. Laser radiation to the prostate was given transurethrally, in a noncontact mode, at the time of the procedure in 2 patients (acute group): 10 W for 300 seconds on the right side of the prostate and 15 W for 180 seconds on the left. In the remaining 4 patients (chronic group), laser radiation was given at 1, 7, 10, and 12 weeks prior to the prostatectomy. Results: In the acute group the average depth of coagulation was 8.5 and 9.0 mm for the laser regimens of 15 W for 180 seconds and the 10 W for 300 seconds, respectively. In the chronic group, the average depth of coagulation was 8.9 mm for both laser regimens studied. In the acute group, there was an ill-defined hemorrhagic ring at the periphery of the lesion. At 1 week, an intact necrotic coagulum was present. At 7 weeks, some of the coagulated tissue had already sloughed off. Longer follow-up at 10 and 12 weeks demonstrated formation of a well-defined cavity with mostly re-epithelialized surface. Conclusions: Our findings suggest that noncontact diode laser (810 nm) irradiation can induce in the human prostate significant coagulation necrosis followed by sloughing of tissue and cavitation of the prostatic urethra.",
author = "Mariela Pow-Sang and Cowan, {Daniel F.} and Eduardo Orihuela and Richard Dyer and Massoud Motamedi and Warren, {Michael M.} and Pow-Sang, {Julio E.}",
year = "1995",
doi = "10.1016/S0090-4295(99)80085-5",
language = "English (US)",
volume = "45",
pages = "790--794",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Thermocoagulation effect of diode laser radiation in the human prostate

T2 - Acute and chronic study

AU - Pow-Sang, Mariela

AU - Cowan, Daniel F.

AU - Orihuela, Eduardo

AU - Dyer, Richard

AU - Motamedi, Massoud

AU - Warren, Michael M.

AU - Pow-Sang, Julio E.

PY - 1995

Y1 - 1995

N2 - Objectives: To evaluate the safety and efficacy of low-power slow-heating diode laser-induced photocoagulation of prostatic tissue for treatment of benign prostatic hyperplasia, we conducted a series of acute and chronic studies using a diode laser (810 nm) to irradiate human prostate. Methods: The study included 6 patients undergoing radical prostatectomy because of malignancy. Laser radiation to the prostate was given transurethrally, in a noncontact mode, at the time of the procedure in 2 patients (acute group): 10 W for 300 seconds on the right side of the prostate and 15 W for 180 seconds on the left. In the remaining 4 patients (chronic group), laser radiation was given at 1, 7, 10, and 12 weeks prior to the prostatectomy. Results: In the acute group the average depth of coagulation was 8.5 and 9.0 mm for the laser regimens of 15 W for 180 seconds and the 10 W for 300 seconds, respectively. In the chronic group, the average depth of coagulation was 8.9 mm for both laser regimens studied. In the acute group, there was an ill-defined hemorrhagic ring at the periphery of the lesion. At 1 week, an intact necrotic coagulum was present. At 7 weeks, some of the coagulated tissue had already sloughed off. Longer follow-up at 10 and 12 weeks demonstrated formation of a well-defined cavity with mostly re-epithelialized surface. Conclusions: Our findings suggest that noncontact diode laser (810 nm) irradiation can induce in the human prostate significant coagulation necrosis followed by sloughing of tissue and cavitation of the prostatic urethra.

AB - Objectives: To evaluate the safety and efficacy of low-power slow-heating diode laser-induced photocoagulation of prostatic tissue for treatment of benign prostatic hyperplasia, we conducted a series of acute and chronic studies using a diode laser (810 nm) to irradiate human prostate. Methods: The study included 6 patients undergoing radical prostatectomy because of malignancy. Laser radiation to the prostate was given transurethrally, in a noncontact mode, at the time of the procedure in 2 patients (acute group): 10 W for 300 seconds on the right side of the prostate and 15 W for 180 seconds on the left. In the remaining 4 patients (chronic group), laser radiation was given at 1, 7, 10, and 12 weeks prior to the prostatectomy. Results: In the acute group the average depth of coagulation was 8.5 and 9.0 mm for the laser regimens of 15 W for 180 seconds and the 10 W for 300 seconds, respectively. In the chronic group, the average depth of coagulation was 8.9 mm for both laser regimens studied. In the acute group, there was an ill-defined hemorrhagic ring at the periphery of the lesion. At 1 week, an intact necrotic coagulum was present. At 7 weeks, some of the coagulated tissue had already sloughed off. Longer follow-up at 10 and 12 weeks demonstrated formation of a well-defined cavity with mostly re-epithelialized surface. Conclusions: Our findings suggest that noncontact diode laser (810 nm) irradiation can induce in the human prostate significant coagulation necrosis followed by sloughing of tissue and cavitation of the prostatic urethra.

UR - http://www.scopus.com/inward/record.url?scp=0028850416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028850416&partnerID=8YFLogxK

U2 - 10.1016/S0090-4295(99)80085-5

DO - 10.1016/S0090-4295(99)80085-5

M3 - Article

C2 - 7747372

AN - SCOPUS:0028850416

VL - 45

SP - 790

EP - 794

JO - Urology

JF - Urology

SN - 0090-4295

IS - 5

ER -