Thermocoagulation effect of diode laser radiation in the human prostate: Acute and chronic study

Mariela Pow-Sang, Daniel F. Cowan, Eduardo Orihuela, Richard Dyer, Massoud Motamedi, Michael M. Warren, Julio E. Pow-Sang

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objectives: To evaluate the safety and efficacy of low-power slow-heating diode laser-induced photocoagulation of prostatic tissue for treatment of benign prostatic hyperplasia, we conducted a series of acute and chronic studies using a diode laser (810 nm) to irradiate human prostate. Methods: The study included 6 patients undergoing radical prostatectomy because of malignancy. Laser radiation to the prostate was given transurethrally, in a noncontact mode, at the time of the procedure in 2 patients (acute group): 10 W for 300 seconds on the right side of the prostate and 15 W for 180 seconds on the left. In the remaining 4 patients (chronic group), laser radiation was given at 1, 7, 10, and 12 weeks prior to the prostatectomy. Results: In the acute group the average depth of coagulation was 8.5 and 9.0 mm for the laser regimens of 15 W for 180 seconds and the 10 W for 300 seconds, respectively. In the chronic group, the average depth of coagulation was 8.9 mm for both laser regimens studied. In the acute group, there was an ill-defined hemorrhagic ring at the periphery of the lesion. At 1 week, an intact necrotic coagulum was present. At 7 weeks, some of the coagulated tissue had already sloughed off. Longer follow-up at 10 and 12 weeks demonstrated formation of a well-defined cavity with mostly re-epithelialized surface. Conclusions: Our findings suggest that noncontact diode laser (810 nm) irradiation can induce in the human prostate significant coagulation necrosis followed by sloughing of tissue and cavitation of the prostatic urethra.

Original languageEnglish (US)
Pages (from-to)790-794
Number of pages5
JournalUrology
Volume45
Issue number5
DOIs
StatePublished - May 1995

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Thermocoagulation effect of diode laser radiation in the human prostate: Acute and chronic study'. Together they form a unique fingerprint.

  • Cite this

    Pow-Sang, M., Cowan, D. F., Orihuela, E., Dyer, R., Motamedi, M., Warren, M. M., & Pow-Sang, J. E. (1995). Thermocoagulation effect of diode laser radiation in the human prostate: Acute and chronic study. Urology, 45(5), 790-794. https://doi.org/10.1016/S0090-4295(99)80085-5