Thermodynamics of association to a molecule immobilized in an electric double layer

Arnold Vainrub; B. Montgomery Pettitt

doi:10.1016/S0009-2614(00)00512-1

Thermodynamics of association to a molecule immobilized in an electric double layer

Arnold Vainrub, B. Montgomery Pettitt

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

A thermodynamic theory of association to a molecule immobilized near a surface has been developed. Exact equations for the binding enthalpy, entropy and equilibrium reaction constant for an immobilized complex are derived. Using linear Poisson-Boltzmann theory of the electric double-layer interaction between an ion-penetrable sphere and a hard plate allows a closed form evaluation. We briefly discuss application of the theory to a DNA chip at high (1 M NaCl) and low (0.01 M NaCl) ionic strength for dielectric and metallic substrates. Predicted strong electrostatic effects suggest the feasibility of electronic control of DNA hybridization and design of chips avoiding the DNA folding problem.

Original language	English (US)
Pages (from-to)	160-166
Number of pages	7
Journal	Chemical Physics Letters
Volume	323
Issue number	1-2
DOIs	https://doi.org/10.1016/S0009-2614(00)00512-1
State	Published - Jun 9 2000
Externally published	Yes

ASJC Scopus subject areas

General Physics and Astronomy
Physical and Theoretical Chemistry

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10.1016/S0009-2614(00)00512-1

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title = "Thermodynamics of association to a molecule immobilized in an electric double layer",

abstract = "A thermodynamic theory of association to a molecule immobilized near a surface has been developed. Exact equations for the binding enthalpy, entropy and equilibrium reaction constant for an immobilized complex are derived. Using linear Poisson-Boltzmann theory of the electric double-layer interaction between an ion-penetrable sphere and a hard plate allows a closed form evaluation. We briefly discuss application of the theory to a DNA chip at high (1 M NaCl) and low (0.01 M NaCl) ionic strength for dielectric and metallic substrates. Predicted strong electrostatic effects suggest the feasibility of electronic control of DNA hybridization and design of chips avoiding the DNA folding problem.",

author = "Arnold Vainrub and Pettitt, {B. Montgomery}",

note = "Funding Information: A.V. thanks Lev N. Bulaevski for discussions. B.M.P. thanks Prof. M. Hogan and Dr. R. Mitra for discussions. This work was partially supported by grants from NIH, Texas Coordinating Board and the Robert A. Welch Foundation. ",

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doi = "10.1016/S0009-2614(00)00512-1",

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T1 - Thermodynamics of association to a molecule immobilized in an electric double layer

AU - Vainrub, Arnold

AU - Pettitt, B. Montgomery

N1 - Funding Information: A.V. thanks Lev N. Bulaevski for discussions. B.M.P. thanks Prof. M. Hogan and Dr. R. Mitra for discussions. This work was partially supported by grants from NIH, Texas Coordinating Board and the Robert A. Welch Foundation.

PY - 2000/6/9

Y1 - 2000/6/9

N2 - A thermodynamic theory of association to a molecule immobilized near a surface has been developed. Exact equations for the binding enthalpy, entropy and equilibrium reaction constant for an immobilized complex are derived. Using linear Poisson-Boltzmann theory of the electric double-layer interaction between an ion-penetrable sphere and a hard plate allows a closed form evaluation. We briefly discuss application of the theory to a DNA chip at high (1 M NaCl) and low (0.01 M NaCl) ionic strength for dielectric and metallic substrates. Predicted strong electrostatic effects suggest the feasibility of electronic control of DNA hybridization and design of chips avoiding the DNA folding problem.

AB - A thermodynamic theory of association to a molecule immobilized near a surface has been developed. Exact equations for the binding enthalpy, entropy and equilibrium reaction constant for an immobilized complex are derived. Using linear Poisson-Boltzmann theory of the electric double-layer interaction between an ion-penetrable sphere and a hard plate allows a closed form evaluation. We briefly discuss application of the theory to a DNA chip at high (1 M NaCl) and low (0.01 M NaCl) ionic strength for dielectric and metallic substrates. Predicted strong electrostatic effects suggest the feasibility of electronic control of DNA hybridization and design of chips avoiding the DNA folding problem.

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Thermodynamics of association to a molecule immobilized in an electric double layer

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