Thioesterification of platelet proteins with saturated and polyunsaturated fatty acids

Michael Laposata, Laszlo Muszbek

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have demonstrated that more than 20 platelet proteins can be acylated with fatty acids via thioester linkages. These include the glycoprotein IX beta chain of glycoprotein Ib, components of the von Willebrand factor receptor on the platelet surface, P-selectin, and α subunits of Gz, Cq, and Gi. Our studies have shown that platelet proteins can be posttranslationally acylated in thioester linkages not only with palmitate but with myristate and also with the eicosanoid precursor fatty acids arachidonate and eicosapentaenoate. Thioesterification of platelet proteins with fatty acids other than palmitate may have significant functional consequences for reversible binding of proteins to membranes.

Original languageEnglish (US)
JournalLipids
Volume31
Issue number3 SUPPL.
StatePublished - Mar 1996
Externally publishedYes

Fingerprint

Platelets
Unsaturated Fatty Acids
saturated fatty acids
polyunsaturated fatty acids
Fatty Acids
Blood Platelets
palmitates
fatty acids
glycoproteins
Palmitates
blood coagulation factors
Proteins
eicosanoids
proteins
Platelet Glycoprotein GPIb-IX Complex
P-Selectin
Eicosanoids
binding proteins
Myristic Acid
Glycoproteins

ASJC Scopus subject areas

  • Food Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Medicine (miscellaneous)

Cite this

Thioesterification of platelet proteins with saturated and polyunsaturated fatty acids. / Laposata, Michael; Muszbek, Laszlo.

In: Lipids, Vol. 31, No. 3 SUPPL., 03.1996.

Research output: Contribution to journalArticle

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