Thioglycine and l-thiovaline: Biologically active H 2S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)2675-2678
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume20
Issue number8
DOIs
StatePublished - Apr 15 2012
Externally publishedYes

Keywords

  • Gasotransmitters
  • Hydrogen sulfidel
  • Thioglycin
  • Thiovalin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Thioglycine and l-thiovaline: Biologically active H 2S-donors'. Together they form a unique fingerprint.

Cite this