Thioglycine and l-thiovaline: Biologically active H 2S-donors

Zongmin Zhou; Margarete Von Wantoch Rekowski; Ciro Coletta; Csaba Szabo; Mariarosaria Bucci; Giuseppe Cirino; Stavros Topouzis; Andreas Papapetropoulos; Athanassios Giannis

doi:10.1016/j.bmc.2012.02.028

Thioglycine and l-thiovaline: Biologically active H ₂S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H ₂S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H ₂S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H ₂S donors hold promise as novel treatments for cardiovascular diseases.

Original language	English (US)
Pages (from-to)	2675-2678
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/j.bmc.2012.02.028
State	Published - Apr 15 2012
Externally published	Yes

Keywords

Gasotransmitters
Hydrogen sulfidel
Thioglycin
Thiovalin

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmc.2012.02.028

Cite this

@article{e5f1c485500b4291ab08fd624311986b,

title = "Thioglycine and l-thiovaline: Biologically active H 2S-donors",

abstract = "Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.",

keywords = "Gasotransmitters, Hydrogen sulfidel, Thioglycin, Thiovalin",

author = "Zongmin Zhou and {Von Wantoch Rekowski}, Margarete and Ciro Coletta and Csaba Szabo and Mariarosaria Bucci and Giuseppe Cirino and Stavros Topouzis and Andreas Papapetropoulos and Athanassios Giannis",

note = "Funding Information: This work has been co-financed by the European Union (European Social Fund –ESF) and Greek national funds through the operational Program {\textquoteleft}Education and Lifelong Learning{\textquoteright} of the National Strategic Reference Framework (NSRF) — Research Funding Program: Thalis, Investing in knowledge society through the European Social Fund to AP, by a grant from the Shriners{\textquoteright} Burns Hospitals (#8661) to CS and by the COST Action BM1005 (ENOG: European network on gasotransmitters). We thank also the University of Leipzig for financial support. ",

year = "2012",

month = apr,

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doi = "10.1016/j.bmc.2012.02.028",

language = "English (US)",

volume = "20",

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journal = "Bioorganic and Medicinal Chemistry",

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T1 - Thioglycine and l-thiovaline

T2 - Biologically active H 2S-donors

AU - Zhou, Zongmin

AU - Von Wantoch Rekowski, Margarete

AU - Coletta, Ciro

AU - Szabo, Csaba

AU - Bucci, Mariarosaria

AU - Cirino, Giuseppe

AU - Topouzis, Stavros

AU - Papapetropoulos, Andreas

AU - Giannis, Athanassios

N1 - Funding Information: This work has been co-financed by the European Union (European Social Fund –ESF) and Greek national funds through the operational Program ‘Education and Lifelong Learning’ of the National Strategic Reference Framework (NSRF) — Research Funding Program: Thalis, Investing in knowledge society through the European Social Fund to AP, by a grant from the Shriners’ Burns Hospitals (#8661) to CS and by the COST Action BM1005 (ENOG: European network on gasotransmitters). We thank also the University of Leipzig for financial support.

PY - 2012/4/15

Y1 - 2012/4/15

N2 - Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

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KW - Gasotransmitters

KW - Hydrogen sulfidel

KW - Thioglycin

KW - Thiovalin

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