Thioglycine and l-thiovaline: Biologically active H 2S-donors

Zongmin Zhou; Margarete Von Wantoch Rekowski; Ciro Coletta; Csaba Szabo; Mariarosaria Bucci; Giuseppe Cirino; Stavros Topouzis; Andreas Papapetropoulos; Athanassios Giannis

doi:10.1016/j.bmc.2012.02.028

Thioglycine and l-thiovaline: Biologically active H ₂S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

Research output: Contribution to journal › Article

43 Scopus citations

Abstract

Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H ₂S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H ₂S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H ₂S donors hold promise as novel treatments for cardiovascular diseases.

Original language	English (US)
Pages (from-to)	2675-2678
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/j.bmc.2012.02.028
State	Published - Apr 15 2012

Keywords

Gasotransmitters
Hydrogen sulfidel
Thioglycin
Thiovalin

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Zhou, Z., Von Wantoch Rekowski, M., Coletta, C., Szabo, C., Bucci, M., Cirino, G., Topouzis, S., Papapetropoulos, A., & Giannis, A. (2012). Thioglycine and l-thiovaline: Biologically active H ₂S-donors. Bioorganic and Medicinal Chemistry, 20(8), 2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028

Thioglycine and l-thiovaline : Biologically active H ₂S-donors. / Zhou, Zongmin; Von Wantoch Rekowski, Margarete; Coletta, Ciro; Szabo, Csaba; Bucci, Mariarosaria; Cirino, Giuseppe; Topouzis, Stavros; Papapetropoulos, Andreas; Giannis, Athanassios.

In: Bioorganic and Medicinal Chemistry, Vol. 20, No. 8, 15.04.2012, p. 2675-2678.

Research output: Contribution to journal › Article

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