Thioglycine and l-thiovaline

Biologically active H 2S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

    Original languageEnglish (US)
    Pages (from-to)2675-2678
    Number of pages4
    JournalBioorganic and Medicinal Chemistry
    Volume20
    Issue number8
    DOIs
    StatePublished - Apr 15 2012

    Fingerprint

    Gasotransmitters
    Oxidative stress
    Bicarbonates
    Vasodilation
    Oxidative Stress
    Cardiovascular Diseases
    Hypertension
    Acids

    Keywords

    • Gasotransmitters
    • Hydrogen sulfidel
    • Thioglycin
    • Thiovalin

    ASJC Scopus subject areas

    • Pharmaceutical Science
    • Drug Discovery
    • Organic Chemistry
    • Molecular Medicine
    • Molecular Biology
    • Clinical Biochemistry
    • Biochemistry

    Cite this

    Zhou, Z., Von Wantoch Rekowski, M., Coletta, C., Szabo, C., Bucci, M., Cirino, G., ... Giannis, A. (2012). Thioglycine and l-thiovaline: Biologically active H 2S-donors. Bioorganic and Medicinal Chemistry, 20(8), 2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028

    Thioglycine and l-thiovaline : Biologically active H 2S-donors. / Zhou, Zongmin; Von Wantoch Rekowski, Margarete; Coletta, Ciro; Szabo, Csaba; Bucci, Mariarosaria; Cirino, Giuseppe; Topouzis, Stavros; Papapetropoulos, Andreas; Giannis, Athanassios.

    In: Bioorganic and Medicinal Chemistry, Vol. 20, No. 8, 15.04.2012, p. 2675-2678.

    Research output: Contribution to journalArticle

    Zhou, Z, Von Wantoch Rekowski, M, Coletta, C, Szabo, C, Bucci, M, Cirino, G, Topouzis, S, Papapetropoulos, A & Giannis, A 2012, 'Thioglycine and l-thiovaline: Biologically active H 2S-donors', Bioorganic and Medicinal Chemistry, vol. 20, no. 8, pp. 2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028
    Zhou Z, Von Wantoch Rekowski M, Coletta C, Szabo C, Bucci M, Cirino G et al. Thioglycine and l-thiovaline: Biologically active H 2S-donors. Bioorganic and Medicinal Chemistry. 2012 Apr 15;20(8):2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028
    Zhou, Zongmin ; Von Wantoch Rekowski, Margarete ; Coletta, Ciro ; Szabo, Csaba ; Bucci, Mariarosaria ; Cirino, Giuseppe ; Topouzis, Stavros ; Papapetropoulos, Andreas ; Giannis, Athanassios. / Thioglycine and l-thiovaline : Biologically active H 2S-donors. In: Bioorganic and Medicinal Chemistry. 2012 ; Vol. 20, No. 8. pp. 2675-2678.
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