Thioglycine and l-thiovaline: Biologically active H 2S-donors

Zongmin Zhou; Margarete Von Wantoch Rekowski; Ciro Coletta; Csaba Szabo; Mariarosaria Bucci; Giuseppe Cirino; Stavros Topouzis; Andreas Papapetropoulos; Athanassios Giannis

doi:10.1016/j.bmc.2012.02.028

Thioglycine and l-thiovaline: Biologically active H ₂S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H ₂S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H ₂S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H ₂S donors hold promise as novel treatments for cardiovascular diseases.

Original language	English (US)
Pages (from-to)	2675-2678
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/j.bmc.2012.02.028
State	Published - Apr 15 2012

Keywords

Gasotransmitters
Hydrogen sulfidel
Thioglycin
Thiovalin

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmc.2012.02.028

Cite this

@article{e5f1c485500b4291ab08fd624311986b,

title = "Thioglycine and l-thiovaline: Biologically active H 2S-donors",

abstract = "Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.",

keywords = "Gasotransmitters, Hydrogen sulfidel, Thioglycin, Thiovalin",

author = "Zongmin Zhou and {Von Wantoch Rekowski}, Margarete and Ciro Coletta and Csaba Szabo and Mariarosaria Bucci and Giuseppe Cirino and Stavros Topouzis and Andreas Papapetropoulos and Athanassios Giannis",

note = "Funding Information: This work has been co-financed by the European Union (European Social Fund –ESF) and Greek national funds through the operational Program {\textquoteleft}Education and Lifelong Learning{\textquoteright} of the National Strategic Reference Framework (NSRF) — Research Funding Program: Thalis, Investing in knowledge society through the European Social Fund to AP, by a grant from the Shriners{\textquoteright} Burns Hospitals (#8661) to CS and by the COST Action BM1005 (ENOG: European network on gasotransmitters). We thank also the University of Leipzig for financial support. ",

year = "2012",

month = apr,

day = "15",

doi = "10.1016/j.bmc.2012.02.028",

language = "English (US)",

volume = "20",

pages = "2675--2678",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd",

number = "8",

}

TY - JOUR

T1 - Thioglycine and l-thiovaline

T2 - Biologically active H 2S-donors

AU - Zhou, Zongmin

AU - Von Wantoch Rekowski, Margarete

AU - Coletta, Ciro

AU - Szabo, Csaba

AU - Bucci, Mariarosaria

AU - Cirino, Giuseppe

AU - Topouzis, Stavros

AU - Papapetropoulos, Andreas

AU - Giannis, Athanassios

N1 - Funding Information: This work has been co-financed by the European Union (European Social Fund –ESF) and Greek national funds through the operational Program ‘Education and Lifelong Learning’ of the National Strategic Reference Framework (NSRF) — Research Funding Program: Thalis, Investing in knowledge society through the European Social Fund to AP, by a grant from the Shriners’ Burns Hospitals (#8661) to CS and by the COST Action BM1005 (ENOG: European network on gasotransmitters). We thank also the University of Leipzig for financial support.

PY - 2012/4/15

Y1 - 2012/4/15

N2 - Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

AB - Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

KW - Gasotransmitters

KW - Hydrogen sulfidel

KW - Thioglycin

KW - Thiovalin

UR - http://www.scopus.com/inward/record.url?scp=84862807204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862807204&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2012.02.028

DO - 10.1016/j.bmc.2012.02.028

M3 - Article

C2 - 22436388

AN - SCOPUS:84862807204

SN - 0968-0896

VL - 20

SP - 2675

EP - 2678

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 8

ER -