Thioglycine and l-thiovaline: Biologically active H 2S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

    Research output: Contribution to journal › Article

    42 Citations (Scopus)

    Abstract

    Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

    Original languageEnglish (US)
    Pages (from-to)2675-2678
    Number of pages4
    JournalBioorganic and Medicinal Chemistry
    Volume20
    Issue number8
    DOIs
    StatePublished - Apr 15 2012

    Fingerprint

    Gasotransmitters
    Oxidative stress
    Bicarbonates
    Vasodilation
    Oxidative Stress
    Cardiovascular Diseases
    Hypertension
    Acids

    Keywords

    • Gasotransmitters
    • Hydrogen sulfidel
    • Thioglycin
    • Thiovalin

    ASJC Scopus subject areas

    • Pharmaceutical Science
    • Drug Discovery
    • Organic Chemistry
    • Molecular Medicine
    • Molecular Biology
    • Clinical Biochemistry
    • Biochemistry

    Cite this

    Zhou, Z., Von Wantoch Rekowski, M., Coletta, C., Szabo, C., Bucci, M., Cirino, G., ... Giannis, A. (2012). Thioglycine and l-thiovaline: Biologically active H 2S-donors. Bioorganic and Medicinal Chemistry, 20(8), 2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028

    Thioglycine and l-thiovaline : Biologically active H 2S-donors. / Zhou, Zongmin; Von Wantoch Rekowski, Margarete; Coletta, Ciro; Szabo, Csaba; Bucci, Mariarosaria; Cirino, Giuseppe; Topouzis, Stavros; Papapetropoulos, Andreas; Giannis, Athanassios.

    In: Bioorganic and Medicinal Chemistry, Vol. 20, No. 8, 15.04.2012, p. 2675-2678.

    Research output: Contribution to journal › Article

    Zhou, Z, Von Wantoch Rekowski, M, Coletta, C, Szabo, C, Bucci, M, Cirino, G, Topouzis, S, Papapetropoulos, A & Giannis, A 2012, 'Thioglycine and l-thiovaline: Biologically active H 2S-donors', Bioorganic and Medicinal Chemistry, vol. 20, no. 8, pp. 2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028
    Zhou Z, Von Wantoch Rekowski M, Coletta C, Szabo C, Bucci M, Cirino G et al. Thioglycine and l-thiovaline: Biologically active H 2S-donors. Bioorganic and Medicinal Chemistry. 2012 Apr 15;20(8):2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028
    Zhou, Zongmin ; Von Wantoch Rekowski, Margarete ; Coletta, Ciro ; Szabo, Csaba ; Bucci, Mariarosaria ; Cirino, Giuseppe ; Topouzis, Stavros ; Papapetropoulos, Andreas ; Giannis, Athanassios. / Thioglycine and l-thiovaline : Biologically active H 2S-donors. In: Bioorganic and Medicinal Chemistry. 2012 ; Vol. 20, No. 8. pp. 2675-2678.
    @article{e5f1c485500b4291ab08fd624311986b,
    title = "Thioglycine and l-thiovaline: Biologically active H 2S-donors",
    abstract = "Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.",
    keywords = "Gasotransmitters, Hydrogen sulfidel, Thioglycin, Thiovalin",
    author = "Zongmin Zhou and {Von Wantoch Rekowski}, Margarete and Ciro Coletta and Csaba Szabo and Mariarosaria Bucci and Giuseppe Cirino and Stavros Topouzis and Andreas Papapetropoulos and Athanassios Giannis",
    year = "2012",
    month = "4",
    day = "15",
    doi = "10.1016/j.bmc.2012.02.028",
    language = "English (US)",
    volume = "20",
    pages = "2675--2678",
    journal = "Bioorganic and Medicinal Chemistry",
    issn = "0968-0896",
    publisher = "Elsevier Limited",
    number = "8",

    }

    TY - JOUR

    T1 - Thioglycine and l-thiovaline

    T2 - Biologically active H 2S-donors

    AU - Zhou, Zongmin

    AU - Von Wantoch Rekowski, Margarete

    AU - Coletta, Ciro

    AU - Szabo, Csaba

    AU - Bucci, Mariarosaria

    AU - Cirino, Giuseppe

    AU - Topouzis, Stavros

    AU - Papapetropoulos, Andreas

    AU - Giannis, Athanassios

    PY - 2012/4/15

    Y1 - 2012/4/15

    N2 - Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

    AB - Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

    KW - Gasotransmitters

    KW - Hydrogen sulfidel

    KW - Thioglycin

    KW - Thiovalin

    UR - http://www.scopus.com/inward/record.url?scp=84862807204&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84862807204&partnerID=8YFLogxK

    U2 - 10.1016/j.bmc.2012.02.028

    DO - 10.1016/j.bmc.2012.02.028

    M3 - Article

    C2 - 22436388

    AN - SCOPUS:84862807204

    VL - 20

    SP - 2675

    EP - 2678

    JO - Bioorganic and Medicinal Chemistry

    JF - Bioorganic and Medicinal Chemistry

    SN - 0968-0896

    IS - 8

    ER -

    Access to Document