Thioglycine and l-thiovaline: Biologically active H 2S-donors

Zongmin Zhou; Margarete Von Wantoch Rekowski; Ciro Coletta; Csaba Szabo; Mariarosaria Bucci; Giuseppe Cirino; Stavros Topouzis; Andreas Papapetropoulos; Athanassios Giannis

doi:10.1016/j.bmc.2012.02.028

Thioglycine and l-thiovaline: Biologically active H ₂S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

Research output: Contribution to journal › Article

43 Scopus citations

Abstract

Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H ₂S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H ₂S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H ₂S donors hold promise as novel treatments for cardiovascular diseases.

Original language	English (US)
Pages (from-to)	2675-2678
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/j.bmc.2012.02.028
State	Published - Apr 15 2012

Fingerprint

Keywords

Gasotransmitters
Hydrogen sulfidel
Thioglycin
Thiovalin

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

Cite this

Zhou, Z., Von Wantoch Rekowski, M., Coletta, C., Szabo, C., Bucci, M., Cirino, G., Topouzis, S., Papapetropoulos, A., & Giannis, A. (2012). Thioglycine and l-thiovaline: Biologically active H ₂S-donors. Bioorganic and Medicinal Chemistry, 20(8), 2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028

Thioglycine and l-thiovaline : Biologically active H ₂S-donors. / Zhou, Zongmin; Von Wantoch Rekowski, Margarete; Coletta, Ciro; Szabo, Csaba; Bucci, Mariarosaria; Cirino, Giuseppe; Topouzis, Stavros; Papapetropoulos, Andreas; Giannis, Athanassios.

In: Bioorganic and Medicinal Chemistry, Vol. 20, No. 8, 15.04.2012, p. 2675-2678.

Research output: Contribution to journal › Article

@article{e5f1c485500b4291ab08fd624311986b,

title = "Thioglycine and l-thiovaline: Biologically active H 2S-donors",

abstract = "Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.",

keywords = "Gasotransmitters, Hydrogen sulfidel, Thioglycin, Thiovalin",

author = "Zongmin Zhou and {Von Wantoch Rekowski}, Margarete and Ciro Coletta and Csaba Szabo and Mariarosaria Bucci and Giuseppe Cirino and Stavros Topouzis and Andreas Papapetropoulos and Athanassios Giannis",

year = "2012",

month = apr

day = "15",

doi = "10.1016/j.bmc.2012.02.028",

language = "English (US)",

volume = "20",

pages = "2675--2678",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Thioglycine and l-thiovaline

T2 - Biologically active H 2S-donors

AU - Zhou, Zongmin

AU - Von Wantoch Rekowski, Margarete

AU - Coletta, Ciro

AU - Szabo, Csaba

AU - Bucci, Mariarosaria

AU - Cirino, Giuseppe

AU - Topouzis, Stavros

AU - Papapetropoulos, Andreas

AU - Giannis, Athanassios

PY - 2012/4/15

Y1 - 2012/4/15

N2 - Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

AB - Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

KW - Gasotransmitters

KW - Hydrogen sulfidel

KW - Thioglycin

KW - Thiovalin

UR - http://www.scopus.com/inward/record.url?scp=84862807204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862807204&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2012.02.028

DO - 10.1016/j.bmc.2012.02.028

M3 - Article

C2 - 22436388

AN - SCOPUS:84862807204

VL - 20

SP - 2675

EP - 2678

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

IS - 8

ER -

Access to Document

10.1016/j.bmc.2012.02.028