Thioglycine and l-thiovaline: Biologically active H 2S-donors

Zongmin Zhou, Margarete Von Wantoch Rekowski, Ciro Coletta, Csaba Szabo, Mariarosaria Bucci, Giuseppe Cirino, Stavros Topouzis, Andreas Papapetropoulos, Athanassios Giannis

    Research output: Contribution to journalArticle

    43 Scopus citations

    Abstract

    Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.

    Original languageEnglish (US)
    Pages (from-to)2675-2678
    Number of pages4
    JournalBioorganic and Medicinal Chemistry
    Volume20
    Issue number8
    DOIs
    StatePublished - Apr 15 2012

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    Keywords

    • Gasotransmitters
    • Hydrogen sulfidel
    • Thioglycin
    • Thiovalin

    ASJC Scopus subject areas

    • Pharmaceutical Science
    • Drug Discovery
    • Organic Chemistry
    • Molecular Medicine
    • Molecular Biology
    • Clinical Biochemistry
    • Biochemistry

    Cite this

    Zhou, Z., Von Wantoch Rekowski, M., Coletta, C., Szabo, C., Bucci, M., Cirino, G., Topouzis, S., Papapetropoulos, A., & Giannis, A. (2012). Thioglycine and l-thiovaline: Biologically active H 2S-donors. Bioorganic and Medicinal Chemistry, 20(8), 2675-2678. https://doi.org/10.1016/j.bmc.2012.02.028