Abstract
Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H 2S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H 2S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H 2S donors hold promise as novel treatments for cardiovascular diseases.
Original language | English (US) |
---|---|
Pages (from-to) | 2675-2678 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 20 |
Issue number | 8 |
DOIs | |
State | Published - Apr 15 2012 |
Keywords
- Gasotransmitters
- Hydrogen sulfidel
- Thioglycin
- Thiovalin
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry