Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro

Chien Liang Liu; Mei Lin Ho; Yu Chun Chen; Cheng Chih Hsieh; Yi Chih Lin; Yu Hsiu Wang; Meng Ju Yang; Hsin Sheng Duan; Bo So Chen; Jyh Fu Lee; Jong Kai Hsiao; Pi Tai Chou

doi:10.1021/jp9080492

Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro

Chien Liang Liu, Mei Lin Ho, Yu Chun Chen, Cheng Chih Hsieh, Yi Chih Lin, Yu Hsiu Wang, Meng Ju Yang, Hsin Sheng Duan, Bo So Chen, Jyh Fu Lee, Jong Kai Hsiao, Pi Tai Chou

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold L_III edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.

Original language	English (US)
Pages (from-to)	21082-21089
Number of pages	8
Journal	Journal of Physical Chemistry C
Volume	113
Issue number	50
DOIs	https://doi.org/10.1021/jp9080492
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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@article{a0ec9606b1eb4e58a342ea00cfdf5b9b,

title = "Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro",

abstract = "We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold LIII edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.",

author = "Liu, {Chien Liang} and Ho, {Mei Lin} and Chen, {Yu Chun} and Hsieh, {Cheng Chih} and Lin, {Yi Chih} and Wang, {Yu Hsiu} and Yang, {Meng Ju} and Duan, {Hsin Sheng} and Chen, {Bo So} and Lee, {Jyh Fu} and Hsiao, {Jong Kai} and Chou, {Pi Tai}",

year = "2009",

doi = "10.1021/jp9080492",

language = "English (US)",

volume = "113",

pages = "21082--21089",

journal = "Journal of Physical Chemistry C",

issn = "1932-7447",

publisher = "American Chemical Society",

number = "50",

}

TY - JOUR

T1 - Thiol-functionalized gold nanodots

T2 - Two-photon absorption property and imaging in vitro

AU - Liu, Chien Liang

AU - Ho, Mei Lin

AU - Chen, Yu Chun

AU - Hsieh, Cheng Chih

AU - Lin, Yi Chih

AU - Wang, Yu Hsiu

AU - Yang, Meng Ju

AU - Duan, Hsin Sheng

AU - Chen, Bo So

AU - Lee, Jyh Fu

AU - Hsiao, Jong Kai

AU - Chou, Pi Tai

PY - 2009

Y1 - 2009

N2 - We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold LIII edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.

AB - We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold LIII edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.

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JO - Journal of Physical Chemistry C

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Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro

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