Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro

Chien Liang Liu; Mei Lin Ho; Yu Chun Chen; Cheng Chih Hsieh; Yi Chih Lin; Yu Hsiu Wang; Meng Ju Yang; Hsin Sheng Duan; Bo So Chen; Jyh Fu Lee; Jong Kai Hsiao; Pi Tai Chou

doi:10.1021/jp9080492

Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro

Chien Liang Liu
, Mei Lin Ho
, Yu Chun Chen
, Cheng Chih Hsieh
, Yi Chih Lin
, Yu Hsiu Wang
, Meng Ju Yang
, Hsin Sheng Duan
, Bo So Chen
, Jyh Fu Lee
, Jong Kai Hsiao
, Pi Tai Chou

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold L_III edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.

Original language	English (US)
Pages (from-to)	21082-21089
Number of pages	8
Journal	Journal of Physical Chemistry C
Volume	113
Issue number	50
DOIs	https://doi.org/10.1021/jp9080492
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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10.1021/jp9080492

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@article{a0ec9606b1eb4e58a342ea00cfdf5b9b,

title = "Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro",

abstract = "We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold LIII edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.",

author = "Liu, \{Chien Liang\} and Ho, \{Mei Lin\} and Chen, \{Yu Chun\} and Hsieh, \{Cheng Chih\} and Lin, \{Yi Chih\} and Wang, \{Yu Hsiu\} and Yang, \{Meng Ju\} and Duan, \{Hsin Sheng\} and Chen, \{Bo So\} and Lee, \{Jyh Fu\} and Hsiao, \{Jong Kai\} and Chou, \{Pi Tai\}",

year = "2009",

doi = "10.1021/jp9080492",

language = "English (US)",

volume = "113",

pages = "21082--21089",

journal = "Journal of Physical Chemistry C",

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publisher = "American Chemical Society",

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T2 - Two-photon absorption property and imaging in vitro

AU - Liu, Chien Liang

AU - Ho, Mei Lin

AU - Chen, Yu Chun

AU - Hsieh, Cheng Chih

AU - Lin, Yi Chih

AU - Wang, Yu Hsiu

AU - Yang, Meng Ju

AU - Duan, Hsin Sheng

AU - Chen, Bo So

AU - Lee, Jyh Fu

AU - Hsiao, Jong Kai

AU - Chou, Pi Tai

PY - 2009

Y1 - 2009

N2 - We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold LIII edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.

AB - We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold LIII edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.

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DO - 10.1021/jp9080492

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JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

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ER -

Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro

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