Thiophene derivatives: A new series of potent norepinephrine and serotonin reuptake inhibitors

Ao Zhang, Guochun Zhou, Suo Bao Rong, Kenneth M. Johnson, Mei Zhang, Alan P. Kozikowski

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.03,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.

Original languageEnglish (US)
Pages (from-to)993-995
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number7
DOIs
StatePublished - Apr 8 2002

Fingerprint

Thiophenes
Dopamine
Serotonin
Norepinephrine
Derivatives
decane
Serotonin and Noradrenaline Reuptake Inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Thiophene derivatives : A new series of potent norepinephrine and serotonin reuptake inhibitors. / Zhang, Ao; Zhou, Guochun; Rong, Suo Bao; Johnson, Kenneth M.; Zhang, Mei; Kozikowski, Alan P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 7, 08.04.2002, p. 993-995.

Research output: Contribution to journalArticle

Zhang, Ao ; Zhou, Guochun ; Rong, Suo Bao ; Johnson, Kenneth M. ; Zhang, Mei ; Kozikowski, Alan P. / Thiophene derivatives : A new series of potent norepinephrine and serotonin reuptake inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 7. pp. 993-995.
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