Thiophene derivatives: A new series of potent norepinephrine and serotonin reuptake inhibitors

Ao Zhang; Guochun Zhou; Suo Bao Rong; Kenneth M. Johnson; Mei Zhang; Alan P. Kozikowski

doi:10.1016/S0960-894X(02)00103-8

Thiophene derivatives: A new series of potent norepinephrine and serotonin reuptake inhibitors

Ao Zhang
, Guochun Zhou
, Suo Bao Rong
, Kenneth M. Johnson
, Mei Zhang
, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.0^3,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.

Original language	English (US)
Pages (from-to)	993-995
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(02)00103-8
State	Published - Apr 8 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(02)00103-8

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title = "Thiophene derivatives: A new series of potent norepinephrine and serotonin reuptake inhibitors",

abstract = "A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.03,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.",

author = "Ao Zhang and Guochun Zhou and Rong, \{Suo Bao\} and Johnson, \{Kenneth M.\} and Mei Zhang and Kozikowski, \{Alan P.\}",

note = "Funding Information: Financial support from the NIH, National Institute on Drug Abuse (DA11548 and DA10458), is gratefully acknowledged. We also thank Dr. Werner Tueckmantel for his assistance in the preparation of the manuscript.",

year = "2002",

month = apr,

day = "8",

doi = "10.1016/S0960-894X(02)00103-8",

language = "English (US)",

volume = "12",

pages = "993--995",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Thiophene derivatives

T2 - A new series of potent norepinephrine and serotonin reuptake inhibitors

AU - Zhang, Ao

AU - Zhou, Guochun

AU - Rong, Suo Bao

AU - Johnson, Kenneth M.

AU - Zhang, Mei

AU - Kozikowski, Alan P.

N1 - Funding Information: Financial support from the NIH, National Institute on Drug Abuse (DA11548 and DA10458), is gratefully acknowledged. We also thank Dr. Werner Tueckmantel for his assistance in the preparation of the manuscript.

PY - 2002/4/8

Y1 - 2002/4/8

N2 - A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.03,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.

AB - A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.03,7]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor.

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U2 - 10.1016/S0960-894X(02)00103-8

DO - 10.1016/S0960-894X(02)00103-8

M3 - Article

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AN - SCOPUS:0037041191

SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Thiophene derivatives: A new series of potent norepinephrine and serotonin reuptake inhibitors

Abstract

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